Role of Histone Acetyltransferases in plant homeostasis

今后几年的一个主要挑战是为不断增加的人口提供粮食。全球对自然资源的需求和可耕地面积的减少正在推高能源和粮食的成本。因此，以可持续的方式增加当前的作物产量至关重要。通过工程改造提高植物对病原体的抗性是管理疾病和减少作物损失的可持续战略。在导致这一提议的工作中，我们确定组蛋白乙酰化是植物生长和免疫的主要转录调节因子。使用模式植物拟南芥，我们确定了多种组蛋白乙酰转移酶参与激素信号。该博士学位的目的是将这项工作转化为使用基因编辑和化学抑制剂的作物，以产生对病原体具有抗性的植物。

A major challenge for the coming years is to provide food for an increasing population. Global demand for natural resources and the decreasing area of arable land are driving up the costs of energy and food. Therefore, it is of great importance to increase the current crop production in a sustainable manner. Engineering plants with increased resistance to pathogens is a sustainable strategy to manage disease and reduce crop losses. In work leading to this proposal we identified histone acetylation as a major transcriptional regulator of plant growth and immunity. Using the model plant Arabidopsis thaliana we identified multiple histone acetyltransferases involved in hormonal signalling. The aim of this PhD is to translate this work to crop plants using gene editing and chemical inhibitors in an effort to generate plants resistant to pathogens.