CORE--CLINICAL

CFAR/CSG临床核心将为多学科 基础，临床和行为科学家之间的合作，以解决 创新研究问题对更好地了解艾滋病毒很重要 疾病的发病机制或更好的方法诊断或治疗艾滋病毒 疾病 具体而言，该核心将促进 艾滋病毒基础和临床研究，提供1）专家临床研究 咨询，以协助基础科学家开发最 用于检验其特定假设的适当方案设计，2） 有经验的临床研究人员招募受试者， 执行议定书，从而为科学家提供基础， 特定假设检验所需的最合适样本，3） 基础科学家和临床研究人员的行为专业知识， 协助他们构思和实施研究方案， 解释研究结果，4）行为科学家有机会 与临床行为研究问题相关的假设检验 人口。 专家临床咨询服务包括 内科/传染病/临床试验副教授 专家研究药剂师/协调员，副教授 生物统计学，谁将担任协调员的行为研究 临床核心内的单位，每个都有8年或以上的学术， 在UCSF的HIV相关临床研究经验。 核心主任和 研究协调员已经协调了一项动态的艾滋病毒临床研究 计划作为旧金山弗朗西斯科总医院，是整合到一个 病人人数超过3，000人的门诊诊所 在艾滋病的不同阶段。 核心总监，研究协调员 行为研究组的科学家们已经在一项 多学科研究的数量，以测试特定的假设， 从基础研究中产生。 完整的临床核心服务将提供 与研究者协商以确定最佳研究设计， 编写书面研究方案和受试者知情同意书 表格，获得IRB批准;保存所需的IRBG 方案通信、受试者招募、获取和 向研究者提供所有方案特异性标本是相关的 临床数据，在超低温下长期储存标本 标本库和行为评估。 这些服务将 使不同的研究人员和多学科团队， 研究人员，有效地探索创新的假设，范围 从HIV分子生物学的临床研究， 妇女和少数民族治疗反应中的辅助因素研究。

The CFAR/CSG Clinical Core will provide a mechanism for multidisciplinary collaboration among basic, clinical and behavioral scientistic to address innovative research questions important to a better understanding of HIV disease pathogenesis or better methods of diagnosis or treatment of HIV disease. Specifically, this Core will facilitate translation between basic and clinical HIV research by providing 1) expert clinical research consultation to assist basic scientists in developing the most appropriate protocol design for testing their specific hypotheses, 2) experienced clinical research staff personnel to recruit subjects and implement protocols thus providing basic scientists in developing the most appropriate specimens needed for specific hypothesis testing, 3) behavioral expertise to basic scientists and clinical researchers to assist them in conceptualizing and implementing research protocols and interpreting findings, and 4) behavioral scientists the opportunity to test hypotheses relevant to behavioral research questions in clinical populations. The expert clinical consultation service includes an associate professor of medicine infectious diseases/clinical trials specialist a research pharmacist/coordinator, an associate professor of biostatistics, who will serve as coordinator of the Behavioral Research Unit within in the Clinical Core, each with 8 or more years of academic, HIV-related clinical research experience at UCSF. The Core Director and Research Coordinator already coordinate a dynamic HIV clinical research program as San Francisco General Hospital that is integrated into an outpatient clinic with a patients base of greater than 3,000 individuals at various stages of HIV disease. The Core Director, Study Coordinator and scientists in the Behavioral Research Unit already collaborate on a number of multidisciplinary studies to test specific hypotheses that emerge from basic research. The full Clinical Core service will provide consultation with the investigators to determine optimal study design, preparation of a written study protocol and subjects informed consent form, obtaining IRB approval and ;maintaining required IRBG correspondence for the protocol, recruitment of subjects, obtaining and providing investigator with all protocol-specific specimens are relevant clinical data, long-term storage of specimens in an ultra-low temperature specimen repository, and behavioral assessments. These services will enable different investigators, and multidisciplinary teams of investigators, to efficiently explore innovative hypotheses, ranging from clinical studies of the molecular biology of HIV to behavioral studies of cofactors in treatment response among women and minorities.