The feasibility of reactivating dormant clinical trial data in England: a proof-of concept study linking infant feeding studies to educational records

1982年至2001年期间，在大奥蒙德街儿童医院（GOSH），4,000多名婴儿参与了11项强化婴儿喂养试验。自他们入学以来，他们的父母和后来的儿童本人都接受了评估，并回答了许多调查问卷。他们对这些试验的贡献创造了一个关于儿童时期丰富婴儿喂养后果的杰出资源。研究结果表明，丰富的婴儿喂养会影响大脑的生长和发育。现在孩子们已经成年，我们的研究将重新激活这些“休眠试验”，看看是否对大脑有长期影响。我们将比较在婴儿时期接受过和没有接受过强化喂养的参与者的学习成绩。这将通过将婴儿喂养试验的信息与参与者的学校记录联系起来来完成，而不联系或识别参与者。通过使用匿名的、关联的试验学校成绩数据，我们可以最大限度地发挥从参与者那里收集的信息的价值，同时提供新的答案，以指导当今儿童关于丰富婴儿喂养的决策。

More than 4,000 infants have been involved in a series of 11 enriched infant feeding trials between 1982 and 2001 at the Great Ormond Street Hospital for Children (GOSH). Since their enrolment, their parents and later the children themselves have undergone assessments and answered numerous questionnaires. Their contributions to these trials have created an outstanding resource about the consequences of enriched infant feeding during childhood. Findings suggest that enriched infant feeding affects brain growth and development. Now that the children are adults, our study will reactivate these "dormant trials" to see whether there are long-term effects on the brain. We will compare school achievement among participants who did and did not receive enriched feeding as infants. This will be done by linking information from the infant feeding trials with participants' school records, without contacting or identifying the participants. By using anonymised, linked trial-school achievement data, we can maximise the value of the information that has already been collected from the participants and at the same time provide new answers to guide decisions about enriched infant feeding for today's children.