CORE--PET FACILITIES

PET设施核心将协调这些方面的初步 PET、临床和CT数据的采集、重建和存档 这是四个项目的共同点。 鲍尔斯博士将担任 这个核心。 所有PET研究都将在Siemens 961 ECAT EXACT HR上进行 47 PET扫描仪位于神经重症监护PET研究设施， 神经科神经外科重症监护室 这个设备 致力于科学研究，研究了一个可爱的脑损伤， 最高优先级。 它配备了所有的生命维持设备 在NNICU的其他地方。 目前，所有的氧-15 进行PET测量所需的放射性药物是 在华盛顿大学医学中心回旋加速器设备中制备 周一至周五早上7点至下午5点由训练有素的操作员值班。 在 为了成功招募急性创伤性脑损伤患者， 就项目1和2而言， 神经重症监护PET研究机构目前的工作之外 小时 在第一年，我们将构建一个交付系统， 目前在Rast Building Imaging中运行的级联加速器 两个街区外的中心。 该系统将提供灵活的学习 病人在下班时间，而不需要回旋加速器操作员。 每个 这四个项目涉及临床和 创伤性脑损伤患者的诊断实验室信息 和脑内出血 在我们的初步研究中， 为此目的手工填写数据表。 第一年，我们将 继续使用我们的纸质数据表格收集数据。 这将使我们 获得数据收集的经验并修改表格 从而提高精度和效率。 这些修订和 修改后的表格将作为修改现有表格的基础。 计算机化数据库系统将在第二年实施。 修改 并实施该临床数据库，以满足这一需求 计划项目应提供效率的改进， 数据收集和检索的标准化和完整性。

The PET Facilities Core will co-ordinate those aspects of the initial acquisition, reconstruction and archiving of the PET, clinical and CT data that are shared among the four projects. Dr. Powers will the Director of this Core. All PET studies will be done on the Siemens 961 ECAT EXACT HR 47 PET scanner located in the Neurocritical Care PET Research Facility in the Neurology Neurosurgery Intensive Care Unit. This facility is dedicated to scientific research with studies of a cute brain injury given top priority. it is outfitted with al the life support equipment available elsewhere in the NNICU. Currently, all oxygen-15 radiopharmaceuticals necessary for performance of the PET measurements are prepared in the Washington University Medical Center Cyclotron Facility staffed by trained operators from 0700-1700, Monday through Friday. In order to successfully recruit patients with acute traumatic brain injury for Projects 1 and 2, it will be necessary to expand working hours of the Neurocritical Care PET Research Facility outside the current working hours. In year 1, we will construct a delivery system from a Tandem Cascade Accelerlator currently operating in the Rast Building Imaging Center two blocks away. This system will provide the flexibility to study patients during off-hours without the need for a cyclotron operator. Each of the four projects involves acquisition and recording of clinical and diagnostic laboratory information on patients with traumatic brain injury and intracerebral hemorrhage. In our preliminary studies we have used data sheets filled out by hand for this purpose. During year 1, we will continue to use our paper data forms to collect data. This will allow us to gain experience with the data collection and modify the forms accordingly to improve accuracy and efficiency. These revised and modified forms will serve as the basis for modifications to an existing computerized database system to be carried out in year 2. Modification and implementation of this clinical database to serve th needs of this program project should provide improvement in the efficiency, standardization and integrity of data collection and retrieval.