The mechanisms of the RNA-binding proteins LARP4A and LARP4B in cancer cell migration and proliferation

本项目的主要研究问题是探讨LARP4A/B RNA结合蛋白在癌细胞侵袭转移中的作用。RNA结合蛋白是一种普遍存在的蛋白质，非调控表达可以通过改变RNA转录本的稳定性和翻译来促进癌症的发展。LARP4A和4B蛋白是一种新的肿瘤转移和侵袭调节蛋白，但其特异的信使核糖核酸靶点和作用机制尚不清楚，它们与信使核糖核酸结构域的结合存在差异。正在测试的假设是LARP4A和LARP4B调节细胞形态、癌细胞和肉瘤细胞的迁移和增殖，并在这些过程的调节中具有不同的作用和靶点。

The primary research question in this project is to investigate the function of the LARP4A/B RNA-binding proteins in cancer cell invasion and metastasis. RNA-binding proteins are ubiquitous proteins and deregulated expression can contribute to cancer development by altering the stability and translation of RNA transcripts. LARP4A and 4B proteins are novel regulators of cancer migration and invasion, however, their specific mRNA targets and mechanism of action are not known and they exhibit differential binding to mRNA domains. The hypothesis being tested is that LARP4A and LARP4B regulate cell morphology, migration and proliferation of carcinoma and sarcoma cells, and have distinct roles and targets in the modulation of these processes.