North-Central California-Center For AIDS Research

描述(由申请人提供)：两个地理位置和 加利福尼亚州中北部的科学联系机构将建立 艾滋病研究发展中心(D-CFAR)将使所有人受益 各机构的研究人员和临床医生，以及 居住在该地区内外的患者。这一D-CFAR将投入 部署成功所需的适当基础设施和领导力 在3年的时间框架内，竞争作为一个完整的CFAR的资金。这是中北部地区 加州发展CFAR(NCCFAR)将利用互补的 加州大学戴维斯分校和病毒学与立克次体机构的优势 加州卫生服务部诊断实验室 (VRDL/CDHS)，并填补制定全面CFAR所需的空白。当时有一位 第三家与行政有关的机构加州大学伯克利分校将被添加到 整体中心。NCCFAR的总体目标将是集中力量 在筹资的头几年，在三个具体的重点领域。第一 将在研究预防策略的同时进行旨在 开发一种有效的HIV-1疫苗。第二个将是获得更好的 通过跨度调查了解疾病发病机制 基础、临床前和临床领域。第三个是翻译 从基础科学和临床前组成部分获得的知识 计划，以开发潜在的新的治疗或预防模式。全 其中三个目标将在改善 向当地民众提供预防性护理和病人护理。NCCFAR将 使用强调相对优势的五个核心进行开发 机构。NCCFAR将由行政核心组织和领导 在加州大学戴维斯分校。试点项目以及对新的研究人员和科学的支持将 由一个发展核心提供资金。基础科学灵长类核心将是 总部设在加州大学戴维斯分校的加州地区灵长类动物设施。病毒学和 位于VRDL/CDHS的免疫学核心将专注于提供基本的 临床病毒学和免疫学基础设施将受益 个人研究人员，以及允许进行复杂的临床 审判。最后，将建立一个临床核心，以进行临床 试验，进行转化性研究，并提供以患者为基础的样本。

DESCRIPTION (Provided by applicant): Two geographically and scientifically linked institutions in North-Central California will establish a Developmental Center for AIDS Research (D-CFAR) that will benefit all of the investigators and clinicians at the respective institutions, as well as the patients living inside and outside that region. This D-CFAR will put into place the appropriate infrastructure and leadership needed to successfully compete for funding as a full CFAR in a 3-year time frame. This North-Central California Developmental CFAR (NCCFAR) will capitalize on the complementary strengths of the institutions, UC Davis and the Virology and Rickettsial Diagnostic Laboratory of the California Department of Health Services (VRDL/CDHS), and fill the gaps needed to develop a full CFAR. At that time a third administratively linked institution, UC Berkeley, will be added to the overall Center. The overall aims of the NCCFAR will be to concentrate efforts during the first years of funding in three specific emphasis areas. The first will be to study prevention strategies along with investigations aimed at developing an effective HIV-1 vaccine. The second will be to gain a better understanding of disease pathogenesis using investigations that span the basic, preclinical and clinical arenas. The third will be to translate knowledge gained from the basic science and preclinical components of the program into developing potential new treatment or prevention modalities. All three of the aims will be carried out in the context of improving the preventative and patient care delivered to local populations. The NCCFAR will be developed using five cores that emphasize the strengths of the relative institutions. The NCCFAR will be organized and led by the Administrative Core at UC Davis. Pilot projects and support for new investigators and science will be funded through a Developmental Core. A basic science Primate Core will be based at the California Regional Primate Facility at UC Davis. A Virology and Immunology Core, located at the VRDL/CDHS, will focus on supplying the basic and clinical virology and immunology infrastructure that will benefit individual investigators, as well as allow for the conduct of complex clinical trials. Lastly, a Clinical Core will be established to conduct clinical trials, perform translational research and supply patient-based samples.