HYPERTONIC SALINE FOR INCREASED ICP FOLLOWING HEAD INJU*

描述（由申请人提供）：难治性颅内高压是 头部受伤儿童的主要死因是 活着越来越多的证据表明，高渗盐水可以减少 颅内压（ICP）足够，如果用作前期治疗， 无法控制的颅内高压牢固的关系 充分控制ICP和结果之间的关系，改善ICP的方法 仍然迫切需要控制。一项前瞻性随机试验， 美国神经病学协会推荐的标准疗法 外科医生，根据儿童调整，标准治疗加高渗盐水 本文提出将40名儿童随机分为两组。主 结果测量将是ICP大于20的百分比时间。 疗效的次要结局指标将包括客观 Morris等人定义的神经恶化，6个月格拉斯哥结局量表， COAT（儿童定向障碍测试）和分散注意力 Test.

DESCRIPTION (provided by applicant): Refractory intracranial hypertension is a leading cause of death in head injured children who reach the hospital alive. There is increasing evidence that hypertonic saline can reduce intracranial pressure (ICP) sufficiently if used as upfront therapy to avoid uncontrollable intracranial hypertension. A well-established relationship between adequate control of the ICP and outcome, methods to improve ICP control are still urgently needed. A pilot prospective randomized trial of standard therapy recommended by the American Association of Neurolological Surgeons, adjusted for children, and standard therapy plus hypertonic saline is proposed. 40 children will be randomized into the 2 groups. The primary outcome measure will be percent time that the ICP is greater than 20. Secondary outcome measures of efficacy will include the frequency of objective neuroworsening as defined by Morris et al., the 6-month Glasgow Outcome Scale, the COAT (Children's Orientation Amnesia Test), and the Divided Attention Test.