Variable compliance chamber to alter pulmonary impedance

描述（由申请人提供）：可变顺应性腔室（VCC）拟用于在肺部疾病治疗期间控制肺输入阻抗。肺阻抗与右心必须泵送的总功有关，在肺部疾病和植入氧合辅助装置时会发生改变（主要以顺应性降低的形式）;这种功的增加可能导致右心衰竭。VCC可以连接到右心或与人工肺结合，以降低右心室的阻抗。VCC的一个应用将是增强原发性或继发性肺动脉高压患者的移植桥或恢复治疗。在第一阶段，确定了顺应性腔室的最佳几何形状和材料，开发了制造技术，测量了腔室的顺应性，并开发了两种用于改变腔室顺应性的方法，并在体外回路中进行了表征。第二阶段的目标是构建一个临床可行的VCC设备，并证明和充分表征其在体内动物模型中控制肺阻抗的应用。在II期结束时，将定义VCC的可制造性，并将详细描述VCC作为独立器械和增强MC 3肺旁人工肺（PAL）性能的器械的体内性能。

DESCRIPTION (provided by applicant): A variable compliance chamber (VCC) is proposed to control pulmonary input impedance during the treatment of pulmonary disease. Pulmonary impedance is related to the total work the right heart must pump against, and it is altered (primarily in the form of decreased compliance) in pulmonary disease and in the implantation of oxygenation assisted devices; this increase in work can lead to right-heart failure. The VCC can be attached to the right-heart or combined with an artificial lung to decrease the impedance seen by the right ventricle. One application of the VCC will be to augment bridge-to-transplant or recovery treatment of patients suffering from primary or secondary pulmonary hypertension. In Phase I, the optimal geometry and material of the compliant chamber were determined, fabrication techniques were developed, the compliance of the chambers were measured, and two methods for varying the compliance of the chamber were developed and characterized in an in vitro circuit. The objective of Phase II is to construct a clinically feasible VCC device, and to demonstrate and fully characterize its application in controlling pulmonary impedance in an in vivo animal model. At Phase II conclusion, manufacturability of the VCC will be defined, and the in vivo performance of the VCC will be thoroughly detailed as both an independent device, and as a device that augments the performance of the MC3 paracorporeal artificial lung (PAL).