BIOLOGY OF ALIMENTARY EPITHELIA IN HEALTH AND DISEASE

哈佛消化疾病中心(HDDC)代表一个由60名研究人员组成的财团，从事与消化系统疾病相关的基础研究。HDDC的科学焦点是上皮结构和功能。主要包括四个方面：1)上皮细胞在消化、吸收和吸收不良中的作用；2)上皮-微生物相互作用在传染病发病机制中的作用；3)上皮细胞相互作用参与宿主防御和疫苗开发；4)上皮细胞生长、分化和致癌。成员实验室主要设在哈佛医学院和3家附属医院：儿童医院医疗中心(CHMC)、贝丝以色列女执事医疗中心(BIDMC)和布里格姆妇女医院(BMH)；7家邻近机构也有代表。人类发展委员会将于1998年9月在玛丽安·R·纽特拉博士的领导下开始其第15个年头，行政核心(A)设在CHMC。1998年，活跃成员的研究基地每年总额超过15,500,000美元，人类发展中心成员正在培训256名博士后研究员和37名博士后学生。26个准会员和人类发展中心(尚未获得独立资助的青年研究人员)也参与其中。四个新修订的科学核心支持中心成员及其受训人员的研究：一个用于电子显微镜、光学和荧光显微镜以及共聚焦显微镜的成像核心(B)；一个用于极化上皮细胞培养、电生理学和异源基因表达的上皮细胞功能核心(C)；一个用于蛋白质和脂肪生物化学、多肽库以及膜分离和分析的生物化学/生物物理学核心(D)；以及一个用于细菌菌株和培养、载体、淋巴细胞分离和分析以及免疫分析的免疫学和微生物学核心(E)。人类发展发展基金为针对年轻研究人员的试点可行性赠款和竞争性小型休假奖励提供资金，以促进新的合作和新技术的获得。丰富计划包括4个研讨会系列，重点是上皮细胞生物学、粘膜免疫学、微生物学、成人和儿童胃肠病学，以及每年2个半天的小型研讨会，重点是与消化疾病相关的基础研究的最新进展。这些人类消化疾病控制中心项目协同工作，以实现人类消化疾病控制中心的长期目标：提高我们对消化系统疾病的了解和知识，从而改善对这些疾病患者的护理。

The Harvard Digestive Diseases Center (HDDC) represents a consortium of 60 investigators engaged in basic research relevant to digestive diseases. The scientific focus of the HDDC is epithelial structure and function. Four broad areas are represented: 1) epithelial cell function in digestion, absorption and malabsorption; 2) epithelial-microbial interactions in the pathogenesis of infectious diseases; 3) epithelial cell interactions involved in host defense and vaccine development, and 4) epithelial cell growth, differentiation and carcinogenesis. Members' laboratories are located primarily in Harvard Medical School and 3 affiliated hospitals: Children's Hospital Medical Center (CHMC), Beth Israel-Deaconess Medical Center (BIDMC), and Brigham and Women's Hospital (BMH); 7 neighboring institutions are also represented. The HDDC will begin its 15th year in September 1998 under the Directorship of Dr. Marian R. Neutra, Ph.D., with the Administrative Core (A) located in CHMC. In 1998, the research base for active members totals over $15,500,000 annually, and HDDC members are training 256 postdoctoral fellows and 37 predoctoral students. 26 Associate Members and HDDC (young investigators not yet independently funded) are also involved. Four newly revised Scientific Cores support the research of Center members and their trainees: an Imaging Core (B) for electron microscopy, light and epifluorescence microscopy, and confocal microscopy; an Epithelial Cell Function Core (C) for polarized epithelial cell-culture, electrophysiology and heterologous gene expression; a Biochemistry/Biophysics Core (D) for protein and lipid biochemistry, peptide libraries, and membrane fractionation and analysis; and an Immunology and Microbiology Core (E) for bacterial strains & culture, vectors, lymphocyte isolation, and analysis, and immunoassays. The HDDC funds Pilot-feasibility grants targeted to young investigators, and competitive Mini-sabbatical awards to foster new collaborations and the acquisition of new technologies. An Enrichment Program includes 4 seminar series focused on epithelial cell biology, mucosal immunology, microbiology, and adult and pediatric gastroenterology, and 2 annual half- day mini-symposia focused on recent advances in basic research relevant to digestive diseases. These HDDC programs work coordinately to address the long-term objective of the HDDC: to enhance our understanding and knowledge of digestive diseases, and thereby improve the care of patients with these conditions.