Stereoretentive enantioconvergent synthesis

本项目将通过实验建立一个不对称合成的新概念：立体保留对映聚合催化。该项目将建立一种概念性的新立体保留二聚化方法，使起始材料的两种对映体都被纳入产品中，而不需要脱羧。将采用几种方法来证明原理证明，并在合成复杂的天然和非天然产物中的应用，然后将用于证明定向合成中立体保留-对映收敛催化的潜力。

This project will experimentally establish a new concept in asymmetric synthesis: stereoretentive enantioconvergent catalysis. This project will establish a conceptually new stereoretentive-dimerisation approach that results in both enantiomers of the starting material being incorporated into the product with no deracemisation required. Several approaches will be pursued to demonstrate proof-of principle, and applications in the synthesis of complex natural and unnatural products will then be used to demonstrate the potential of stereoretentive-enantioconvergent catalysis in target-orientated synthesis.