Developmental Exposure to Oxytocin--Animal Models

该项目的目的是研究发育暴露于催产素（OT）的短期和长期后果。将在实验中检查OT的时间参数、剂量和特异性，这些实验将用于确定动物模型，以便对项目II-IV进行更细致的分析。这个项目的动物将在项目IV中用于分析cfo的变化，这些变化是在开发过程中使用OT治疗的直接结果。基本功能，包括生长模式，繁殖和基础内分泌参数将检查在大鼠和田鼠。所研究的行为和内分泌指标是已被证明对成年期OT敏感的功能。要测量的行为包括出生、母性行为、交配和自然发情，以及疼痛阈值。需要测量的内分泌参数包括类固醇激素和肽激素（包括OT和AVP）。我们还将研究这些动物的生长模式和代谢激素，包括CCK，胰岛素，以及葡萄糖。

The purpose of the project is to examine the short-term and long-term consequence of developmental exposure of oxytocin (OT). The time parameters, doses and specificity of OT will be examined, in experiments that will be used to define animal models for the more fine-grained analyses of Projects II-IV. Animals from this project will be used in Project IV in an analysis of cFos changes as an immediate result of treatment with OT during development. Basic functions, including patterns of growth, reproduction and basal endocrine parameters will be examined in rats and voles. The behaviors and endocrine measures to be studied are functions which have been shown to be sensitive to OT in adulthood. Among the behaviors to be measured are birth, maternal behavior and mating and natural estrus, along with pain thresholds. Among the endocrine parameters to be measured are steroid and peptide hormones (including OT and AVP). We also will examine the growth patterns of these animals and metabolic hormones including CCK, insulin, as well as glucose.