Patient Oriented Outcomes of Prophylactic Mastectomy

描述（由申请人提供）：女性患乳腺癌的风险增加 面临着一个关于预防性乳房切除术在他们的 努力预防乳腺癌。尽管有证据表明 预防性乳房切除术后发生乳腺癌的风险降低，其 对其他患者导向结局的影响尚不清楚。尤其如此 对于发生乳腺癌后接受预防性乳房切除术的女性， 对侧乳房拟议的研究将通过以下方式解决这一缺陷： 从确定的女性中收集有关以患者为导向的结果的信息， 在六个HMO中进行的预防性乳房切除术的有效性研究 美国各地以社区为基础的人群。该研究包括321 因家族病史而进行双侧预防性乳房切除术的女性， 乳腺癌或良性乳腺疾病的个人病史和1，161名女性 接受单侧预防性乳房切除术的乳腺癌患者， 对侧乳房使用焦点小组和邮寄调查，研究将 调查对考虑预防的女性重要的五个结果 乳房切除术：愿意向类似女性推荐预防性乳房切除术; 乳腺癌风险相关的压力;身体形象;性活动， 满意度;和健康感知，重要的协变量， 分析中考虑的因素包括自发生后的时间和发生后的并发症 预防性乳房切除术和人口统计学特征，如年龄和 教育调查结果将与那些在类似的妇女， 未接受预防性乳房切除术，但风险增加 乳腺癌是由于家族或个人乳腺癌史或个人 良性乳腺疾病史。这项研究将提供关键信息， 对于考虑进行预防性乳房切除术的妇女及其保健提供者， 目前的决定是基于缺乏长期信息， 以病人为导向的结果。

DESCRIPTION (provided by applicant): Women at increased risk for breast cancer face a difficult decision about the role of prophylactic mastectomy in their effort to prevent breast cancer. While evidence suggests a substantial reduction in breast cancer risk occurs after prophylactic mastectomy, its effect on other patient-oriented outcomes is unclear. This is particularly true for women undergoing prophylactic mastectomy after breast cancer occurred in the contralateral breast. The proposed study will address this deficiency by gathering information on patient-oriented outcomes from women identified for an ongoing study of the efficacy of prophylactic mastectomy in six HMO community-based populations across the United States. The study includes 321 women with bilateral prophylactic mastectomy done for a family history of breast cancer or a personal history of benign breast disease and 1,161 women with breast cancer who underwent unilateral prophylactic mastectomy of the contralateral breast. Using focus groups and a mailed survey, the study will investigate five outcomes important to women considering prophylactic mastectomy: willingness to recommend prophylactic mastectomy to similar women; breast cancer risk-related stress; body image; sexual activity and satisfaction; and health perception, Important covariates that will be considered in the analyses include time since and complications after prophylactic mastectomy and demographic characteristics such as age and education. Results of the survey will be compared to those in similar women who have not undergone prophylactic mastectomy but who are at increased risk for breast cancer due to family or personal history of breast cancer or personal history of benign breast disease. This study will provide critical information for women and their health care providers considering prophylactic mastectomy, a decision currently based on a dearth of information on long-term patient-oriented outcomes.