CORE--BEHAVIOR

行为核心的目的是通过定量评估感觉运动和认知行为端点来评估大鼠和小鼠创伤性脑损伤后神经回路的功能状态。本研究旨在评估大鼠液体性脑损伤相关的神经行为缺陷和小鼠控制性皮质影响，并在可能的情况下评估神经行为终点与神经病理、神经生理和分子标志物之间的关系。在核心中使用的感觉运动整合和认知测试已被证明对这些创伤性脑损伤模型产生的损伤敏感，在中度至重度损伤程度下，在顶叶颞叶皮层、海马、丘脑和白质中产生明显的病理。

The purpose of the behavioral core is to evaluate the functional status of neural circuitry following traumatic brain injury in rats and mice, by quantitatively assessing sensorimotor and cognitive behavioral endpoints. Paradigms are designed to assess neurobehavioral deficits associated with fluid percussive TBI in rats, and controlled cortical impact in mice, and to evaluate, when possible, the relation between neurobehavioral endpoints and neuropathological, neurophysiological, and molecular markers. The tests of sensorimotor integration and cognition used in the core have been demonstrated to be sensitive to insults produced by these TBI models, which, at moderate to severe levels of injury severity, produce overt pathology in the pariototemporal cortex, hippocampus and thalamus, and white matter.