MRI AND RT PA TREATMENT OF EMBOLIC STROKE

描述（改编自申请人摘要）：本申请将开发 预测溶栓结局的磁共振成像（MRI）标准 大鼠局灶性脑栓塞缺血后。本提案的目的是 评估MRI测量是否可以识别可逆性受损组织， 识别脑组织，当用 血栓溶解剂申请人还将调查 溶栓干预的特点和预测可以通过定量 MRI可测量参数的变化。提出了两个具体目标： 目的1-预测栓塞性卒中后出血性转化（HT）， 使用MRI对大鼠进行溶栓。具体目标2a-识别可逆性损害 大鼠栓塞性脑卒中和溶栓后缺血组织MRI研究 特定目的2B B确定MRI预测 rt-PA溶栓干预。申请人将采用多模式 MRI和图像分析方法学结合组织学终点 表征栓塞性卒中的脑组织，并预测 溶栓治疗的结果。长期目标是提供新的和 与急性卒中治疗相关的重要信息， 血栓溶解

DESCRIPTION (Adapted from Applicant's Abstract): This application will develop magnetic resonance imaging (MRI) criteria to predict outcome of thrombolysis after focal cerebral embolic ischemia in rats. The goal of this proposal is to assess whether the MRI measurements can identify reversibly damaged tissue and identify cerebral tissue that is destined to hemorrhage when treated with a thrombolytic agent. The applicants would also investigate whether the efficacy of thrombolytic intervention can be characterized and predicted by quantitative changes in MRI measurable parameters. Two specific aims are proposed: Specific Aim 1-To predict hemorrhagic transformation (HT) after embolic stroke and thrombolysis in rats using MRI. Specific Aim 2a-To identify reversibly damaged ischemic tissue after embolic stroke and thrombolysis in rat using MRI. Specific Aim 2b B To determine the ability of MRI to predict the efficacy of thrombolytic intervention with rt-PA. The applicants would employ multimodality MRI and image analysis methodology in combination with histological endpoints to characterize cerebral tissue subjected to embolic stroke and to predict outcome of thrombolytic therapy. The long-term goal is to provide new and important information relevant to the treatment of acute stroke by thrombolysis.