PREDOCTORAL TRAINING: BIOORGANIC/BIOINORGANIC CHEMISTRY

这个修订后的提案寻求继续支持跨学科，博士前培训计划集中在生物有机和生物无机化学。最初要求支助12个毕业生见习职位，后来增加到15个。来自生物系、化学系和化工系的13名教员将参与培养博士预科生。该计划的目的是培养学生在化学设计，合成，阐明和功能应用的有机和含金属的生物重要性分子。由于强调跨学科研究，学生将被训练应用化学的观点，在考虑结构和机制的基础上，探索生物功能。通过化学合成和设计，学员将能够探测、修改和创造生物功能。在这次修订中，我们试图强调跨学科的培训，特别是鼓励我们的学生发展对化学工具和原理在生物系统中的有力应用的理解。设施将包括加州理工学院的两个部门以及贝克曼研究所的研究和教学设施，化学家和生物学家在共享的实验室资源中心进行研究。课程设置将为学生提供化学和生物学的基础，但重点将放在研究经验背景下的培训上。据估计，加州理工学院这个项目的潜在学生人数已经超过70人，他们都具有出色的素质和才能，并且对化学和生物学的交叉研究充满热情。我们提出这个生物有机化学和生物有机化学的培训项目，利用化学设计来探索生物功能，成为加州理工学院的一个焦点，在这里，学生们在化学和生物学的界面上接受学术和工业研究的领导角色的培训。

This revised proposal seeks continued support for an interdisciplinary, predoctoral training program centered in bioorganic and bioinorganic chemistry. Support is requested initially for 12 graduate trainee positions, and increasing to 15. Thirteen faculty from the Divisions of Biology and Chemistry and Chemical Engineering will participate in training predoctoral students. The aim of the proposed program is the training of students in the chemical design, synthesis, elucidation, and functional application of organic and metal-containing molecules of biological importance. With this emphasis on interdisciplinary research, students will be trained to apply a chemical perspective, grounded in considerations of structure and mechanism, to explore biological function. Through chemical synthesis and design, trainees will become able to probe, modify, and create biological function. In this revision we seek to emphasize training across the disciplines, in particular to encourage our students to develop an understanding of where chemical tools and principles can be powerfully applied in biological systems. Facilities will include the research and teaching facilities of both Divisions at Caltech as well as the Beckman Institute, where chemists and biologists conduct research in shared laboratory resource centers. The course curriculum will provide students with a foundation in both chemistry and biology, but strong emphasis will be placed on training in the context of the research experience. The potential pool of students for the program already at Caltech is estimated as greater than 70 students, all of outstanding quality and talent, and with excitement for conducting research at the interface of chemistry and biology. We propose this training program in bioorganic and bioorganic chemistry, using chemical design to explore biological function, to become a focal point at Caltech, where students are trained for leadership roles in both academic and industrial research at the interface of chemistry and biology.