How does DNA damage alter nuclear mRNA export in humans?

人类细胞调节哪些mrna从细胞核输出到细胞质，以响应DNA损伤。在这个项目中，您将使用计算和分子生物学方法来提供mRNA输出如何响应DNA损伤的全基因组视图。该项目将利用一系列尖端技术，包括高通量DNA测序，CRISPR和RNA干扰来解剖生物过程。将提供计算和分子生物学技术方面的培训，确保学生为21世纪的定量生物学做好充分准备。

Human cells regulate which mRNAs are exported from the nucleus to the cytoplasm in response to DNA damage. In this project you will use computational and molecular biology approaches to provide a genome wide view of how mRNA export changes in response to DNA damage. The project will utilise a range of cutting edge techniques including high throughput DNA sequencing, CRISPR and RNA interference to dissect the biological process. Training in both computational and molecular biology techniques will be provided ensuring the student is fully prepared for 21st century quantitative biology.