Core--Animal facility

动物核心动物核心的目标是为计划项目的研究人员提供科学和技术支持，以设计和执行他们的研究。这一核心的具体目标是：1.在动物中诱发糖尿病，并保持动物的健康状态(定期监测是否符合适用于糖尿病动物的健康标准)，并严格控制血糖控制水平；2.协调计划项目调查人员从实验动物中获取和分配组织和体液；3.为涉及动物特殊饮食和药物治疗的方案的科学和执行提供协助；4.在使用糖尿病及其并发症的动物模型方面为计划项目的新调查人员提供培训。该计划项目的调查人员将由一个团队提供服务，该团队由我们的动物研究单位主任(V.Monnier，医学博士，T.Kern，博士)和一名60%的全职研究助理组成，他将与CWRU动物资源中心的工作人员合作承担设施的日常运营)。

Summary ANIMAL CORE The objective of the Animal Core is to provide investigators of the Program Project with scientific and technical support for the design and execution of their studies. The specific aims of this core are: 1. To induce diabetes in animals and maintain the animals in a healthy state (routinely monitored for compliance with standards of health appropriate for diabetic animals) and in carefully controlled levels of glycemic control, 2. To coordinate the acquisition and distribution of tissues and body fluids from experimental animals among Program Project investigators, 3. To provide assistance with scientific and execution of protocols involving special diet and pharmacological treatments in animals, and 4. To provide training for new investigators of the Program Project in the use of animal models of diabetes and its complications. Service to the Investigators of the Program Project will be provided by a team consisting of the director of our unit for animal studies (V. Monnier, MD, T. Kern, PhD), and a 60% FTE Research Assistant who will assume the day-to-day operation of the facility in collaboration with the staff of the Animal Resources Center at CWRU).