This project will hunt for aquatic bladder carcinogens by chlorinating authentic and simulated drinking water samples under controlled laboratory cond

流行病学研究表明，长期饮用含氯饮用水与患膀胱癌的风险增加有关。这种联系的原因仍然不清楚，尽管人们认为与消毒副产物有关。这些是在饮用水处理过程中，前体化合物(有机和无机)与消毒剂(最常见的是氯)之间的反应而产生的。已知饮用水中存在数百种消毒副产物，这既反映了前体的多样性，也反映了涉及的化学物质的复杂性。然而，在它们的数量中并没有确定的膀胱癌致癌物质。因此，来自分析化学、毒理学和流行病学的证据之间存在不匹配。一个看似合理的解释是，饮用水中的膀胱癌物质被遗漏或忽视了。该项目将通过在受控的实验室条件下对真实和模拟的饮用水样本进行氯化处理来寻找水生膀胱癌致癌物质。这些反应的产物将通过一系列分析技术进行分析，重点放在具有已知膀胱癌致癌物质化学功能的分子上。

Epidemiological studies have shown long-term consumption of chlorinated drinking water is associated with an enhanced risk of developing bladder cancer. The cause of this link remains obscure, although it is assumed that disinfection byproducts are implicated. These are generated during drinking water treatment from reactions between precursor compounds (both organic and inorganic) and disinfectants (chlorine being the commonest). Many hundreds of disinfection byproducts are known to occur in drinking water, which reflects both precursor diversity and the complexity of the chemistry involved. However, there are no definite bladder carcinogens amongst their number. Thus, there is a mismatch between the evidence from analytical chemistry, toxicology and epidemiology. A plausible explanation is that bladder carcinogens in drinking water are being missed or overlooked. This project will hunt for aquatic bladder carcinogens by chlorinating authentic and simulated drinking water samples under controlled laboratory conditions. The products from these reactions will be analysed by a range of analytical techniques, focussing on molecules with the chemical functionality found in known bladder carcinogens