PARASITE CYTOADHERENCE MECHANISM IN MATERNAL MALARIA

目前正在合成两类化合物(1)三萜类化合物和 (2)吲哚及相关杂环。三萜类化合物相当于一个大的 从角鲨烯中提取的植物五环天然产物 骑自行车。我们已经开始了一个程序来修改两个常见的成员 这一类，熊果酸和齐墩果酸，在寻找小说 生物活性。在过去的一年里，我们已经合成了近 这三个三萜类化合物的100个衍生物及其迄今的结果 指出四种不同的重要生物学活动，包括 预防癌症和抗炎。因此，在一个 结构活性研究，几种合成的三萜类化合物揭示了一种 对一氧化氮合酶(NOS)的抑制作用 小鼠巨噬细胞中的γ-干扰素或脂多糖。一套不同的 三萜类化合物诱导HL-60白血病细胞分化。在……里面 此外，合成三萜类化合物的第三个亚基最近 已被发现具有抑制前列腺癌生长的活性 细胞，无细胞毒性。最后，这些小说中的一些 三萜类化合物抑制人类肿瘤细胞系中的环氧合酶-2。 对于所有这些新化合物，质谱学是必不可少的 角色化工具。

Two classes of compounds are being synthesized (1) triterpenes and (2) indoles andrelated heterocycles. Triterpenoids eonstitute a large group of plant pentacyclic natural products derived from squalene cyclization. We have begun a program to modify two common members of this class, ursolic and oleanolic acid, in a search for novel biological activity. Over the past year, we have synthesized nearly 100 derivatives of these triterpenoids and our results to date indicate four distinct significant biological activities, including cancer chernoprevention and anti-inflammation. Thus, in a structure-activity study, several synthetic triterpenoids reveal a marked inhibition of nitric oxide synthesis (NOS) induced by gamma-interferon or LPS in mouse macrophages. A different set of triterpenoids induces differentiation of HL-60 leukemia cells. In addition, a third sub-group of synthetic triterpenoids has recently been found to be active in suppressing the growth of prostate cancer cells, without cytotoxicity. Finally, some of these novel triterpenoids inhibit cyclooxygenase-2 in a human tumor cell line. For all these new compounds, mass spectrometry is an essential characterization tool.