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IN VITRO FIBRIL FORMATION BY MUTANT ALPHA SYNUCLEIN: PARKINSON DISEASE

IN VITRO FIBRIL FORMATION BY MUTANT ALPHA SYNUCLEIN: PARKINSON DISEASE
突变型α突触核蛋白的体外纤维形成:帕金森病
批准号:
6478956
负责人:
PETER T LANSBURY
金额:
$5.36万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-07-01 至 2002-06-30

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中文摘要
翻译
滥用药物通过吸毒传染给婴儿 怀孕是在一个国家计划,获得胎粪监测 从医院的新生儿中选出代表不同阶层的 在整个人口中。 出乎意料的高阳性率 四氢大麻素的结果需要进一步分析 先前检查过的胎粪样本中保留的剩余部分 以确定标准方法(FPIA)是否给出假阳性。 设计了一种质谱法,类似于已发表的 方法,但修改为处理存储的样本。 述质谱 方法表明总体比率较低。 取得的成果是 由专门从事这类研究的商业实验室验证, 分析和最近收集的样本已提交给 分析.
英文摘要
Transmission of abused drugs to infants through drug use during pregnancy is being monitored in a state program that obtains meconium from newborns in hospitals selected to represent the various strata among the whole population. Unexpectedly high rates of positive results for tetrahydrocannabinoids has necessitated further analysis of the reserved remainder of thepreviously examined meconium samples to determine whether the standard method (FPIA) gives false positives. A mass spectrometric method was devised, similar to a published method, butmodified to handle stored samples. The mass spectrometric method indicated a lower overall rate. Results obtained have been verified by a commercial laboratory that specializes in this type of assay and further recently collected samples have been submitted for analysis.
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Facility for drug testing in alpha-syn transgenic drosophila & new models of PD
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    7009789
  • 项目类别:
  • 资助金额:
    $8.57万
  • 财政年份:
    2005
  • 负责人:
    PETER T LANSBURY
  • 依托单位:
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  • 负责人:
    PETER T LANSBURY
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A High-Throughput Assay-SOD1 Aggregation Inhibitors(RMI)
  • 批准号:
    7022025
  • 项目类别:
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  • 财政年份:
    2005
  • 负责人:
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  • 批准号:
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  • 项目类别:
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