Reducing HIV Risk in AOD Abusing Multi-Cultural Youth

描述（由申请方提供）：拟定研究涉及 艾滋病毒预防科学与社区实践之间的持续脱节， 医学研究所（1998，2000）和美国国立卫生研究院（NIH） (2000，2001）。 值得注意的优先事项是，需要将有效的艾滋病毒 针对青少年的社区预防干预措施 直接服务于高危人群 这项研究的主要目的是 评估认知行为（CB）艾滋病毒青少年的有效性 预防干预措施的适应性设计（CB-A）， 社区组织（CBO）的工作人员。 将比较CB-A 时间和注意力匹配的标准护理条件（SC）， 临床试验，其中两者都是由成熟的CBO提供的， 工作人员 类似于我们最初开发的CB， CB-A是一项基于研究的疗效临床试验， 创新的行为技能培训组合，激励增强， 先前证明的干预措施的预防复发组成部分 有效，并在CDC（1999年）的艾滋病毒预防纲要中确定 有证据证明有效的干预措施。 在设计随机 临床试验和CB-A干预以实现最佳翻译， 技术转让，我们的学术大学医学中心的研究团队已经 与社区组织网络建立了密切的伙伴关系和协作， 作为艾滋病毒预防和治疗提供者， 处于社会经济不利地位的种族/族裔少数群体 佛罗里达州迈阿密-戴德县的社区。 这个县有着 艾滋病毒/艾滋病的负担，是最密集的多元文化和城市地区， 该州 使用为青年服务的社区组织作为招聘网站， 160名男性和160名女性青少年将主要是少数民族， 收入，文化多样性，性活跃的年轻人，最近的历史， 酒精和其他药物滥用（AOD）。 本研究的主要目的是 评估关键变量是否介导和调节 干预和艾滋病风险行为的结果。 这项研究意义重大 因为它解决了迫切需要制定一个有效的，高度针对性的 CBO从业人员可用于减少艾滋病毒传播的干预措施 在这个极其脆弱和危险的人群亚组中， 受艾滋病毒影响最严重的地区， 种族/民族健康差距的普遍问题。

DESCRIPTION (provided by applicant): The proposed study addresses the persistent disconnect between HIV prevention science and community practice as urgently identified by the Institute of Medicine (1998,2000) and the NIH (2000,2001). Of noted priority is the need to transfer effective HIV prevention interventions targeting adolescents to community-based settings that directly serve the highest risk groups. This study's primary aim is to assess the effectiveness of a Cognitive Behavioral (CB) HIV adolescent prevention intervention in an adapted design (CB-A) for implementation in Community-Based Organizations (CBOs) by CBO staff. The CB-A will be compared to a time and attention matched Standard Care condition (SC) in a randomized clinical trial, in which delivery of both is by well-established CBOs and staff. Similar to our originally developed CB that has shown great promise in a research-based efficacy clinical trial, CB-A incorporates the same innovative mix of behavioral skills training, motivational enhancement, and relapse prevention components of interventions previously demonstrated to be effective and identified in the CDC's (1999) Compendium of HIV Prevention Interventions with Evidence of Effectiveness. In designing the randomized clinical trial and the CB-A intervention for optimal translation and technology transfer, our academic university medical center research team has formed a close partnership and collaboration with a network of CBOs, well-integrated as HIV prevention and treatment providers serving the surrounding, socioeconomically disadvantaged racial/ethnic minority communities of Miami-Dade County, Florida. This county carries the greatest HIV/AIDS burden and is the most densely multicultural and urban area within the state. Using youth-serving CBOs as recruitment sites, the proposed sample of 160 male and 160 female adolescents will be predominantly minority, low income, culturally diverse, sexually active youths with recent histories of Alcohol and Other Drug (AOD) abuse. The scondary aims of this proposed study are to evaluate if key variables mediate and moderate relationships between the intervention and HIV risk behavior outcomes. This study is significant because it addresses the urgent need to develop an effective, highly targeted intervention that is usable by CBO practitioners to reduce HIV transmission behaviors in this extremely vulnerable and risky population subgroup, in an area of the country that is disproportionately affected by HIV and the pervasive national problem of racial/ethnic health disparities.