LSD and Serotonin Receptor Function

描述（由申请人提供）： 精神分裂症是一种精神疾病，其核心症状包括 妄想、思维和言语混乱以及幻觉。神经 幻觉形成的基质目前还不清楚。在这 应用，生物化学和行为实验将进行， 检查迷幻药麦角酸的作用部位 二乙基酰胺（LSD）。LSD被认为主要通过以下方式来调节其作用： 5-羟色胺-2A（5-HT 2a）和5-羟色胺-2C（5-HT 2c）受体。具体目标我会 检查5-HT 2A和5-HT 2C受体对诱导 即早基因c-fos在LSD处理后大鼠脑中的表达。具体目标H 将利用直接微输注来分离涉及的脑部位。 LSD诱导的辨别刺激最后，Specific Aim Ill将检查 是否有5-HT 2A和5-HT 2C受体的功能改变， 反复服用迷幻药一个长期的目标是了解神经机制 LSD的作用，一种强效致幻剂，以及这些神经过程如何可能 在精神分裂症等疾病状态下功能失调。

DESCRIPTION(Provided by applicant): Schizophrenia is a psychiatric disorder with core symptoms that include delusions, disorganized thought and speech, and hallucinations. The neural substrate for the formation of hallucinations is, at present, unclear. In this application, biochemical and behavioral experiments will be performed to examine the loci of action of the hallucinogenic drug lysergic acid diethylamide (LSD). LSD is thought to mediate its actions primarily through serotonin-2A (5-HT2a) and serotonin-2C (5-HT2c) receptors. Specific Aim I will examine the contribution of 5-HT2A and 5-HT2c receptors to the induction of the immediate early gene, c-fos, in rat brain after LSD treatment. Specific Aim H will utilize direct microinfusion to isolate which brain site(s) are involve in the LSD-induced discriminative stimulus. Finally, Specific Aim Ill will examine whether there are functional alterations of 5-HT2A and 5-HT2c receptors after repeated LSD exposure. A long-term goal is to understand the neuronal mechanism of action of LSD, a potent hallucinogen, and how these neuronal processes might be dysfunctional in a disease state such as schizophrenia.