Elucidating the pathological role and predictive value of mental health disorder risk genes

精神分裂症和抑郁症等精神健康障碍是常见的，往往使人衰弱。我们DNA中的基因在谁会患上这些疾病中起着很大的作用，许多风险基因已经被确定。我们将研究这些风险基因何时以及如何被“开启”，以弄清楚它们是如何导致疾病的，并准确预测谁是患精神疾病的高风险人群。这些进步将帮助我们了解疾病的起因并改进治疗方法。

Mental health disorders such as schizophrenia and depression are common and often debilitating conditions. The genes in our DNA play a large role in who develops these disorders and many risk genes have been identified. We will investigate when and how these risk genes are “switched on” to work out how they cause disease and to accurately predict who is at high risk of developing a mental health disorder. These advances will help us to understand disease causation and to improve treatments.