Comprehensive Training Grant in Bone Biology and Disease

描述(由申请人提供)：此修改后的申请 UAB骨生物学和疾病综合研究培训计划 提供发展所需的严格的跨学科教育 这一领域的独立研究科学家。该培训计划的基础是 UAB代谢性骨病中心(主任：J.McDonald，M.D.)， 已被资助为5个国家研究核心中心之一(第30页)。25名教职员工 培训计划的成员是根据他们的互补性来选择的 临床和基础研究方面的研究专长，动态研究计划， 和训练记录。由于该计划的跨学科性质， 教职员工定义了立即可用的协作项目(58个 并可用于招聘和指导。基础研究项目包括 方法和技术在基础生物学分析中的应用 骨丢失、骨质疏松症、其他代谢性骨病和糖皮质激素 诱导性骨丢失；牙周病；骨转移癌；以及 生物材料/植入研究。临床研究项目(流行病学、 预防、结果和有效性研究；诊断学的发展； 和临床试验)利用临床教员在Long 长期、多机构研究，包括老年科和儿科 人口。培训计划将由麦克唐纳博士管理(主席： 病理学)由两名副主任(T·林肯博士、L.莫兰德、 M.D.)，谁将负责制定个人培训计划， 整合研究和教学部分，并监督正式的 和一个咨询委员会(M.Jeffcoat，D.M.D.，L.Lucas，Ph.D.， R.Mayne，Ph.D.，J.Murphy Ulrich，Ph.D.，K.Saag，M.D.)，他们将成为 负责招聘，对正式申请进行竞争性审查，以及 监督实习生的进度。基础研究的实习生将被要求 参加全部或部分综合生物医学科学计划(主任： 林肯)，它提供必要的基于器官和细胞的基础科学培训 从方法驱动的分子生物学和遗传学分析过渡到 临床相关、以问题为基础的研究。K30翻译研究 项目(PI：Moland)为临床研究人员提供智力 和管理技能是设计和实现 信息丰富的临床研究和试验，以及状态的背景 美术基础科学知识。申请资助三名博士后和 三名博士后实习生。博士前实习生将被录取到IBS， 生物医学工程、细胞和分子生物学，或医学博士/博士研究生 UAB的课程。

DESCRIPTION (provided by applicant): This revised application for a comprehensive Research Training Program in Bone Biology and Disease at UAB offers the rigorous interdisciplinary education required for the development of independent research scientists in this field. The Training Program is based in the UAB Center for Metabolic Bone Disease (Director: J. McDonald, M.D.), which has been funded as 1 of 5 national Research Core Centers (P30). The 25 faculty members of the Training Program have been selected based on their complementary research expertise in clinical and basic research, dynamic research programs, and training records. Due to the interdisciplinary nature of the Program, the faculty has defined collaborative projects (58) that are available immediately and can be used in recruitment and guidance. Basic research projects include the use of approaches and technologies in the analysis of the basic biology of bone loss; osteoporosis, other metabolic bone diseases, and glucocorticoid induced bone loss; periodontal disease; cancer metastatic to bone; and biomaterials/implant research. The clinical research projects (epidemiology, prevention, outcomes, and effectiveness studies; development of diagnostics; and clinical trials) exploit the participation of clinical faculty in long term, multi institutional studies, including geriatric and pediatric populations. The Training Program will be administered by Dr. McDonald (Chair: Pathology) assisted by two Associate Directors (T. Lincoln, Ph.D.; L. Moreland, M.D.), who will be responsible for development of individual training plans, integration of research and didactic components, and oversight of formal requirements, and an Advisory Committee (M. Jeffcoat, D.M.D., L. Lucas, Ph.D., R. Mayne, Ph.D., J. Murphy Ulrich, Ph.D., K. Saag, M.D.), who will be responsible for recruitment, competitive review of formal applications, and oversight of trainees progress. Trainees in basic research will be required to take all or part of the Integrative Biomedical Sciences Program (Director: Lincoln), which provides organ and cell based basic science training necessary for transition from methods driven molecular biology and genetics analyses into clinically relevant, problem based studies. The K30 Translational Research Program (PI: Moreland) provides clinical investigators with the intellectual and administrative skills essential for the design and accomplishment of informative clinical studies and trials, together with a background in state of the art basic science knowledge. Funding is requested for three predoctoral and three postdoctoral trainees. Predoctoral trainees will be enrolled in the IBS, Biomedical Engineering, Cell and Molecular Biology, or M.D./Ph.D. Graduate Programs at UAB.