Antigen discovery and antibody engineering against avian paramyxovirus

新城疫病毒是一种高度传染性的急性呼吸道病毒，其感染禽类的致死率高达100%。它对家禽业、特别是发展中国家的家禽业以及小规模养殖户构成了重大威胁。目前的疫苗只对某些毒株完全有效，对更新、更强的毒株几乎没有保护作用。该项目的目的是试图通过在细胞培养中表达改良的新城疫病毒融合蛋白来开发针对这些新出现的病毒株的疫苗。然后，这些抗体将被用来在体内产生针对多种菌株的广泛中和抗体。这些将被用来进一步研究F蛋白的结构，以期创造一种有效的家禽重组疫苗来对抗病毒。AFS，ENWW

Newcastle Disease Virus is a highly infectious Avulavirus with up to a 100% fatality rate in the birds it infects. It constitutes a major threat to the poultry industry, especially in the developing world, as well as to small scale farmers. Current vaccines are only fully effective against some strains of the virus and confer little protection against newer, more virulent strains. The aims of this project are to attempt to develop a vaccine against these newly emerging strains of virus through the expression of modified Newcastle disease virus fusion proteins, in cell culture. These will then be used to generate broadly neutralising antibodies against multiple strains in-vivo. These will be used to further study the F protein structure with a view to creating an effective recombinant vaccine, for poultry, against the virus. AfS, ENWW