LONG TERM FOLLOW UP OF THE NIDDK LTD

描述：（改编自研究者摘要）NIDDK肝脏 移植数据库（LTD）是一个多中心登记处， 肝移植（LT）的连续候选人，在 1990年和1994年，美国三大肝移植中心 States.因此，它是唯一科学设计和实施的 一项多中心研究，其中一个大型LT队列的近期经验 这个国家的候选人和接受者可以被严格分析。的 努力建立这一详细和高质量的资源进行了 根据一项为期7年的NIDDK合同，该合同将于1997年12月结束。宝贵 本研究收集的信息包括临床和实验室数据 按方案和事件发生时收集，并富含 协议活检从高比例的收件人，一个银行的系列 血清标本和虚拟组织库由于目前的合同 仅提供平均3年的随访，主题范围 利用这个综合数据库， 有限公司目前的计划是继续对 移植受者的另一个5年，通过下一阶段的 移植后阶段，当原有疾病复发时， 免疫抑制和再次移植的长期副作用是 最有可能发生。因此，协调中心在以下方面的支持下， 三个LTD临床中心的研究者将能够 获得平均10年（8-12年）的完整随访， 观察研究前、中、后记录的信息 移植预计拟议的努力将产生巨大的成果， 科学和临床的重要性，这可能直接影响未来 移植候选者选择和移植后患者 管理

DESCRIPTION: (Adapted from Investigator's abstract) The NIDDK Liver Transplantation Database (LTD) is a multicenter registry of more than 1500 consecutive candidates for liver transplantation (LT), recruited between 1990 and 1994, by three major liver transplant centers in the United States. As such, it is the only scientifically designed and implemented multicenter study from which the recent experience of a large cohort of LT candidates and recipients in this country can be rigorously analyzed. The effort to build this detailed and high quality resource was carried out under a 7-year NIDDK contract which ends in December 1997. Valuable information collected in this study includes clinical and laboratory data collected by protocol and at a time of events, and it is enriched with protocol biopsies from a high proportion of recipients, a bank of serial serum specimens, and a virtual tissue bank. Since the current contract only provided for follow-up of 3 years on average, the range of topics that could be investigated, using this comprehensive data base, is limited. The current plan is to continue the follow-up of the cohort of transplant recipients for another 5 years through the next phase of the post-transplantation period, when recurrence of the original disease and long-term adverse effects of immunosuppression and re-transplantation are most likely to occur. Thus, the Coordinating Center, with the support of the investigators of the three LTD clinical centers, will be able to obtain complete follow-up for an average of 10 years (8-12 years) to observe the information recorded in the study before, during an dafter transplantation. The proposed effort is expected to yield results of great scientific and clinical importance which could directly influence future transplant candidate selection and post-transplantation patient management.