Mechanisms of gastrin-CCKBR/gastrin-annexin II signaling as indicators for non-invasive health monitoring during aging

除了红细胞和白细胞外，已知血液中还含有一系列组织来源的内皮细胞。许多这样的细胞表达蛋白质，如肽激素胃泌素及其同源受体CCKBR和Annexin II，这些蛋白质参与组织内稳态，其活性与健康和疾病都有关。理解它们作为健康生物标记物的效用的关键是从机制上理解这些生物标记物的正常和异常信号。该项目旨在利用Asstrimmune开发的新过滤技术，结合Smythe Lab在细胞信号和成像方面的专业知识，开发一种高灵敏度的生物检测系统，通过该系统，血液中循环细胞中信号输出的变化可以用于识别衰老的关键变化点，这表明需要进一步的干预。该项目将包括在曼斯菲尔德的阿斯特里姆蒙安置。

In addition to erythrocytes and leucocytes, blood is known to contain cells of endothelial origin from a range of tissues. Many such cells express proteins, such as the peptide hormone gastrin, together with its cognate receptors CCKBR and Annexin II that are involved in tissue homeostasis, and whose activity is associated both with health AND disease. Key to understanding their utility as health biomarkers is a mechanistic understanding of normal and abnormal signaling of such biomarkers. This project aims to use novel filtration technology developed by Asstrimmune, together with expertise in cell signaling and imaging in the Smythe Lab, to develop a highly sensitive biological detection system by which changes in signaling outputs in cell circulating in blood, may be used for the identification of critical change points in aging, indicating a need for further intervention. The project will include a placement at Asstrimmune, Mansfield.