Aerosol Delivery of Influenza Vaccine Candidates and Role of Local Immune Response in Pigs

甲型流感病毒是上个世纪主要流行病的罪魁祸首。它能够感染不同的宿主，如人、猪和鸟，以及高突变率，是抗击这种病原体的主要挑战。猪是甲型流感病毒的自然宿主，在新病毒的出现中发挥着关键作用，能够感染人和禽类毒株。目前的疫苗策略依赖于中和抗体，而中和抗体依赖于菌株，因此需要每年更新。在这项研究中，将分析新的广泛保护性候选疫苗，并对不同的给药途径进行免疫原性和保护潜力的比较。这将是第一次有可能研究猪肺组织驻留记忆T细胞的作用及其在流感感染和保护背景下的功能。该项目遵循BBSRC“生物科学促进健康”的优先领域，为猪的健康提供了新的见解，并使从一个健康的角度研究甲型流感病毒成为可能。AFS，ENWW

Influenza A virus is responsible for the major pandemics in the last century. Its ability to infect different hosts, such as human, pigs and birds, and the high mutation rate represents a major challenge in fighting this pathogen. Pigs are natural host of influenza A virus and play a critical role in the emergence of new viruses, being able to be infected with human and avian strains. Current vaccine strategies rely on neutralising antibodies which are strain dependent and therefore need to be updated every year. In this study new broadly protective vaccine candidates will be analysed and different routes of administration compared for their immunogenicity and protection potential. For the first time it will be possible to study the role of lung tissue resident memory T cells in pigs and their function in the context of influenza infection and protection. This project follows the BBSRC "Bioscience for Health" priority area, giving new insights into pigs' health and allowing the study of influenza A virus in a One Health perspective. AfS, ENWW