Arene Activation by Transition Metals

描述：（由申请人提供）拟议研究的目的 是在有机合成中使用过渡金属的能力， 芳族底物亲核加成。两个主要奋进领域 研究内容如下：（1）烷氧基苯三羰基铬配合物 其中烷氧基是手性的衍生物将用作底物 用于不对称碳亲核加成反应。这场 方案是在高浓度下形成手性取代的环己烯酮。 对映体过量(2)氯代芳烃的环戊二烯基钌配合物 将用于实现亲核芳族取代，作为 一种复杂的多肽--瑞斯托康A糖苷配基的全合成 与重要的糖肽类抗生素万古霉素相关的芳基醚， 替考拉宁。

DESCRIPTION: (provided by applicant) The objectives of the proposed research are to use in organic synthesis the ability of transition metals to activate aromatic substrates toward nucleophilic addition. Two main areas of endeavor will be studied: (1) Chromium tricarbonyl complexes of alkoxybenzene derivatives, in which the alkoxy group is chiral, will be used as substrates for asymmetric carbon nucleophile addition reactions. The outcome of this protocol is the formation of chiral substituted cyclohexenones in high enantiomeric excess. (2) Cyclopentadienylruthenium complexes of chloroarenes will be used to effect nucleophilic aromatic substitution as a key step in the total synthesis of the aglycone of ristocetin A, which is a complex peptido aryl ether related to the important glycopeptide antibiotics vancomycin and teicoplanin.