C-H Bond Activation in Synthesis of Organic Molecules

描述：（申请人的描述）拟议方案的重点是 通过C-H键活化合成复杂的天然产物。的可能性 在复杂的背景下，这些转化的位点选择性 底物具有显著的合成潜力。假设这些目标是 实现了新颖独特的合成策略，用于组装天然 产品可以预见。该计划将重点发展 用于直接C-H活化的过渡金属试剂和催化剂。 C-H活化反应的选择性将通过使用 合适杂原子/官能团（在大多数情况下为亚胺基团）以活化和 将金属配合物直接连接到成对的二烷基上。按照这一逻辑，新 将在以下三个方面探讨四元立体中心的方法： 天然产物的种类（盾子草生物碱、真杀鱼素生物碱和 选择的铽衍生的天然产物）。

DESCRIPTION: (Applicant's Description) The proposed program focuses on synthesis of complex natural products via C-H bond activation. The possibility of site selectivity of these transformations in the context of complex substrates is of significant synthetic potential. Assuming such goals were realized novel and unique synthetic strategies for the assembly of natural products can be envisioned. This program will focus on development of transition metal reagents and catalysts for directed C-H activation. Selectivity of C-H activation reactions will be achieved through the use of a suitable heteroatom/functionality (imine group in most cases) to activate and direct metal complexes to geminal dialkyl groups. Following this logic, new ways to quaternary stereogenic centers will be explored in the context of three classes of natural products (aspidosperma alkaloids, teleocidin alkaloids and selected terpene-derived natural products).