BIOENERGETICS OF EXERCISE-INDUCED MENSTRUAL DISTURBANCES

描述：(从申请人的摘要中扫描)抑制 剧烈运动导致的月经周期可导致不孕不育，严重 骨脱矿，增加骨折风险，并可能增加风险 心血管疾病。最近在人类和动物身上的发现强烈地 表明运动引起的月经紊乱主要是由 能量利用率低，不受身体压力等其他因素的影响 运动本身。虽然一些研究已经量化了能量平衡 与短期内血浆生殖激素水平的下降有关， 与临床诱导和逆转有关的生物能量学 运动女性中公认的月经紊乱仍不清楚。 这项提议的第一个具体目标是检验这样一种假设： 运动性月经的严重程度与月经严重程度直接相关 扰动和负能量平衡的大小。除了……之外 减肥，对人类的横断面研究表明，运动导致 月经紊乱与适应机制有关 能量，即循环代谢激素和底物的变化，以及 减少24小时能量消耗的组成部分，如代谢率。 由于使用动物模型进行的体内和体外研究表明 关键代谢激素和底物在调节中的机械作用 GnRH神经元活动与能量平衡变化的前瞻性研究 在人类中，现在需要识别时间进程和大小 EIMD发生发展过程中潜在关键代谢信号的变化。这个 这项提议的第二个具体目标是检验以下假设 运动引起的月经紊乱是由一种 由保存能量的适应性机制定义的特定代谢状态。 这项研究的意义与不孕不育的情况有关，延迟 青春期，无排卵，神经性厌食症，运动性闭经，以及 最近发现黄体期紊乱和无排卵的发生率很高 女性即使在娱乐水平上也要进行自行车运动。我们期待着结果 以提供新的有用的信息，以便制定具体的 关于锻炼和饮食习惯的建议 维持正常的排卵月经周期和适当的血药浓度 循环中的雌激素和黄体酮。结果也将扩大我们的 黄曲霉毒素对生殖功能调节机制的认识 能源可获得性。

DESCRIPTION: (Scanned from the applicant's abstract) The suppression of menstrual cyclicity due to strenuous exercise can cause infertility, severe bone demineralization, increase fracture risk, and possibly increase the risk of cardiovascular disease. Recent findings in humans and animals have strongly suggested that exercise-induced menstrual disturbances are primarily caused by low energy availability and not by other factors, such as the physical stress of exercise per se. While some studies have quantified energy balance associated with short-term decreases in plasma levels of reproductive hormones, the bioenergetics associated with the induction and reversal of clinically recognized menstrual disturbances in exercising women remain unclear. The first specific aim of this proposal is to test the hypothesis that there is a direct relationship between the severity of exercise-induced menstrual disturbances and the magnitude of negative energy balance. In addition to weight loss, crosssectional studies in humans suggest that exercise-induced menstrual disturbances are associated with adaptive mechanisms to conserve energy, i.e., alterations in circulating metabolic hormones and substrates, and reductions in components of 24 h energy expenditure such as metabolic rate. Since in vivo and in vitro studies using animal models have suggested mechanistic roles for key metabolic hormones and substrates in the modulation of GnRH neuronal activity with changes in energy balance, prospective studies in humans are now necessary to identify the time course and magnitudes of change of potential key metabolic signals during the development of EIMD. The second specific aim of this proposal is to test the hypothesis that exercise-induced menstrual disturbances are triggered by the development of a particular metabolic state defined by adaptive mechanisms to conserve energy. The significance of this research relates to conditions of infertility, delayed puberty, anovulation, anorexia nervosa, exercise-induced amenorrhea, and the recently identified high incidence of luteal phase disturbances and anovulatory cycles in women exercising even at recreational levels. We expect the results of these studies to provide new and useful information for making specific recommendations regarding the exercise and dietary practices concomitant with maintaining normal, ovulatory menstrual cycles and adequate levels of circulating estrogen and progesterone. The results will also expand our understanding of the mechanism of the modulation of reproductive function by energy availability.