CORE--MORPHOLOGY FACILITY

形态核心的目标是提高中心研究人员进行消化和肝脏研究的能力。形态核心致力于为科学家提供高质量的服务和支持，致力于教授技术并提供对胃肠道和肝脏组织进行形态分析所需的试剂。该中心自1997年7月开始向消化和肝病分子研究中心的研究人员提供服务和试剂以来，已经有了长足的发展，并取得了极大的成功。西尔伯格博士于1998年成为形态核心的主任。核心的发展导致了加里·斯温博士被聘为技术总监。西尔伯格博士和斯温博士通过向中心研究人员教授技术和协助开发免疫组织化学新抗体的方案，在扩大核心的科学方面发挥了至关重要的作用。由于增加了两名全职技术人员，中心能够及时向中心调查人员提供优质服务。以下描述将概述形态核心所提供的服务。一些主要调查人员产生的形态数据将作为可以预期的工作类型和质量的例子提出。这一核心的一个重要方面是其调查人员之间的合作和互动。形态核心位于临床研究大楼的6楼，在胃肠病科科学研究人员旁边的房间里，所有中心的研究人员都可以很容易地接近。由于形态核心距离用户实验室很近，它已成为中心调查人员、研究员和技术人员在执行免疫组织化学或使用成像设备时进行协作和咨询的重要工具。通过这些互动已经建立了协作，我们预计将以这种方式促进未来的协作。重要的是，分子生物学核心位于形态核心的对面，允许在组织采购和分析(例如，组织库、HE切片和RNA提取)中进行紧密的互动。

The objective of the Morphology Core is to enhance the ability of the Center Investigators to perform digestive and liver research. The Morphology Core strives to provide high quality service and support to scientists with a commitment to teaching the techniques and providing the reagents necessary to perform morphologic analysis of gastrointestinal tract and liver tissues. This Core has grown substantially and has been extremely successful since July 1997, when it initiated services and provided reagents to Investigators of the Center for Molecular Studies in Digestive and Liver Disease. Dr. Silberg became the Director of the Morphology Core in 1998. The growth of the Core resulted in the hiring of Gary Swain, Ph.D. as the Technical Director. Drs. Silberg and Swain have been essential in expanding the scientific aspects of the Core by teaching techniques to Center Investigators and assisting in the development of protocols for new antibodies for immunohistochemistry. With the addition of two full time technicians, the Core has been able to provide quality services in a timely manner to the Center Investigators. The following description will outline the services provided by the Morphology Core. Morphologic data generated by some of the principle investigators will be presented as examples of the type and quality of work that can be expected. An important aspect of this core has been the collaboration and interactions that have occurred among its investigators. The Morphology Core is located on the 6th floor of the Clinical Research Building, in rooms adjacent to the scientific investigators in the Division of Gastroenterology, and easily accessible to all Center Investigators. Due to the close proximity of the Morphology Core to the user laboratories, it has become an important vehicle for Center Investigators, fellows, and technicians to collaborate and consult while performing immunohistochemistry or using the imaging equipment. Collaborations have been built through these interactions and we anticipate fostering future collaborations in this fashion. Importantly, the Molecular Biology Core is located across the hall from the Morphology Core, allowing for cohesive interactions in tissue procurement and analysis (e.g., Tissue bank, H&E sections and RNA extractions).