CORE--NEUROTOXICOLOGY

研究人员在研究核心4中进行的研究旨在 描述遗传、衰老和环境之间的相互作用， 神经退行性疾病的发病机制，以及阐明 某些神经毒剂的作用机制。研究核心的目标 继续促进实验室研究人员之间的整合， 和同事参与人类研究，以促进发展一个新的 神经退行性疾病的环境和遗传危险因素 疾病，并建立啮齿动物行为实验室供中心使用 investigators.神经毒理学研究核心包括八个 来自环境卫生部、神经病学部、 外科学、病理学、医学遗传学和流行病学，五个附属机构 来自环境卫生、神经病学和 华盛顿大学的生物工程研究人员和来自外部的研究人员 研究机构除了广泛参与重大问题外， 神经毒理学，科斯塔博士与弗隆博士合作探索遗传 对氧磷酶基因多态性与有机磷易感性 杀虫剂并与Checkoway博士一起研究单胺氧化酶B的多态性 和D2受体作为帕金森病的危险因素？的疾病。博巴赫医生 继续研究铅对非人类灵长类动物的发育毒性 并承担了开发啮齿动物行为实验室的任务， Drs.科斯塔和弗隆，继博士离开吉尔伯特从 大学马丁博士加入研究中心 阿尔茨海默病的额外力量？的疾病。调查人员已经开发出 广泛的合作，并利用设施的核心，在他们的 合作研究。未来的计划包括刺激增加 核心研究者之间的互动，实施啮齿动物行为 实验室，促进生态遗传学的概念，在神经毒理学 社区，促进核心研究人员的研究，开发一个 神经退行性疾病的遗传和环境风险 疾病，并催化更多的合作和刺激新的线 的研究。

The research conducted by investigators in Research Core 4 seeks to characterize the interplay between genetics, aging, and the environment in the pathogenesis of neurodegenerative diseases, as well as to elucidate the mechanism of action of certain neurotoxicants. The goals of the Research Core are to continue to facilitate the integration between laboratory investigators and colleagues involved in human studies, to foster the development of a new program project on environmental and genetic risk factors in neurodegenerative diseases, and to develop a rodent behavioral laboratory for use by Center investigators. The Neurotoxicology Research Core consists of eight Investigators, from the Departments of Environmental Health, Neurological Surgery, Pathology, Medical Genetics, and Epidemiology, five Affiliate Investigators from the Departments of Environmental Health, Neurology, and Bioengineering at the University of Washington, and investigators from outside research institutions. In addition to broad involvement in major issues in neurotoxicology, Dr. Costa collaborates with Dr. Furlong exploring genetic polymorphisms in paraoxonase and susceptibility to organophosphorus insecticides and with Dr. Checkoway on polymorphisms of monoamine oxidase B and D2 receptors as risk factors in Parkinson?s disease. Dr. Burbacher continues his studies of developmental toxicity of lead in non-human primates and has taken on the task of developing a rodent behavioral laboratory, with Drs. Costa and Furlong, following the departure of Dr. Gilbert from the university. The addition of Dr. Martin to the research core has provided additional strength in Alzheimer?s disease. The investigators have developed extensive collaborations and have utilized the facility cores in their collaborative research. Future plans include the stimulation of increased interactions between Core investigators, implementation of a rodent behavioral laboratory, fostering the concept of ecogenetics in the neurotoxicology community, facilitating research by the Core investigators, developing a program project in genetic and environmental risks in neurodegenerative diseases, and catalyzing additional collaborations and stimulating new lines of research.