CORE--RESPIRATORY EFFECTS

本核心的两个目标是：1)了解如何 室内外空气污染导致人类呼吸道疾病 (包括哮喘)，以及2)宿主因素(即敏感性)如何影响 致病过程。这一核心研究了大量人群的流行病学和 在实验室研究中的较小小组。因此，它参与了 在多项研究中观察了急性和慢性呼吸影响。 该核心与暴露评估(EA)核心和核心密切合作 参与研究设计和生物统计学。有几个正在进行的 这个核心工作的研究项目：有一个主要的纵向 空气污染对儿童慢性呼吸影响的人群研究 在南加州的不同社区(由CARB支持)。一个 额外拨款(由EPA、NIEHS、NHLBI支持)现在正在评估膳食 因素和一些遗传多态。有两个正在进行的实验 健康和哮喘受试者心肺反应的室内研究 使用环境颗粒物浓缩器(由EPA和 嗨)。

The two objectives of this Core are: 1) to understand how indoor and outdoor air pollution contributes to human respiratory diseases (including asthma), and 2) how host factors (i.e., sensitivity) influence the pathogenic process. This Core studies large populations epidemiologically and smaller groups in experimental chamber studies. Thus, it is involved in looking at both acute and chronic respiratory effects in multiple studies. This Core works closely with the Exposure Assessment (EA) Core and the Cores involved in study design and biostatistics. There are several ongoing research projects in which this Core works: There is a major longitudinal population study of chronic respiratory effects of air pollution in children in different communities in Southern California (supported by CARB). An additional grant (supported by EPA, NIEHS, NHLBI) is now evaluating dietary factors and some genetic polymorphisms. There are two ongoing experimental chamber studies of cardio-pulmonary responses of health and asthmatic subjects to particulates using an ambient particle concentrator (supported by EPA and HEI).