THERAPY DEVELOPMENT FOR MENTALLY ILL DRUG ABUSERS

描述：（申请人摘要） 本申请要求支持独立科学家奖（K 02）， 凯特·凯里博士，并描述申请人的研究和职业生涯 发展规划申请人以前和目前的NIDA资助的研究 重点关注严重和持续性精神病患者中的物质使用和滥用 门诊病人她的职业目标包括（a）获得开发方面的专业知识 增强改变动机的疗法，（B）指导治疗结果 研究;（c）指导青年科学家。该提案描述了两个 目前已资助的项目有三个。项目1是一项正在进行的NIMH资助的研究， 正在评估两种预防干预措施对患有 严重的精神疾病参与者被随机分配到一种物质的使用 减少组、艾滋病毒风险减少组或仅标准治疗 组，所有设计作为门诊精神病治疗的补充。两 小组在5周内进行10次会议，并纳入教育， 动机增强和行为技能组成部分。参与者 完成基线、治疗后、3个月和6个月随访评估。 项目2是NIDA资助的一期治疗开发项目。这种顺序 研究计划包括（a）心理测量研究，以确定 足够可靠和有效以作为结果的测量，和（B） 开发和初步试点测试一个附加模块， 精神分裂症和药物使用障碍门诊患者参与 药物治疗未来的计划包括继续治疗开发过程 从项目2开始，设计更加复杂， 激励性干预的有效性， 以技能为基础的治疗，并确定反应者的特征， 无应答者。申请人的职业发展计划侧重于活动 旨在促进向高级地位和领导地位的持续进步 在外地这些措施包括通过课程继续发展技能， 与领先的治疗开发中心协商;与 当地同事的富有成效的小组;进行有计划的研究;以及 为初级科学家提供研究指导。该奖项将使 申请人受保护的时间（教学救济和夏季支持）继续 发展她的研究，对药物滥用的治疗中， 精神病

DESCRIPTION: (Applicant's Abstract) This application requests support for an Independent Scientist Award (K02) for Kate Carey, Ph.D., and describes the applicant's research and career development plans. The applicant's previous and current NIDA-funded research focuses on substance use and abuse among severely and persistently mentally ill outpatients. Her career goals include (a) acquiring expertise in developing therapies that enhance motivation for change, (b) conducting treatment outcome research, and (c) mentoring junior scientists. This proposal describes two of three currently funded projects. Project 1 is an ongoing NIMH-funded study that is evaluating the efficacy of two prevention interventions for adults with severe mental illness. Participants are randomly assigned to a substance use reduction group, a HIV risk reduction group, or a standard treatment only group, all designed as supplements to outpatient psychiatric treatment. Both groups run for 10 sessions over 5 weeks, and incorporate education, motivational enhancement and behavioral skills components. Participants complete baseline, post-treatment, 3-month and 6-month follow-up assessments. Project 2 is a NIDA-funded Phase I therapy development project. This sequential research plan includes (a) psychometric research to identify measures that are sufficiently reliable and valid to serve as measures of outcome, and (b) the development and initial pilot testing of an add-on module designed to enhance readiness of outpatients with schizophrenia and drug use disorders to engage in drug treatment. Future plans involve continuing the therapy development process started in Project 2 with more sophisticated designs, optimizing the long-term effectiveness of motivational interventions by supplementing them with skills-based therapies, and identifying characteristics of responders and non-responders. The applicant's career development plans focus on activities designed to facilitate continued progress toward senior status and leadership in the field. These include continued skill development through courses and consultation with leading therapy development centers; collaboration with a productive group of local colleagues; conducting programmatic research; and providing research mentoring to junior scientists. This award would allow the applicant protected time (teaching relief and summer support) to continue to develop her research on the treatment of substance abuse among the severely mentally ill.