Neurology Outcomes Research:Clinical Trials/ Training

描述(申请人提供)：对该病发病机制的新见解 帕金森氏病(PD)，可获得更广泛的 抗帕金森病治疗，更好的评估和治疗工具的演变 监测疾病进展结合在一起改变了目前的管理 以及与PD相关的临床治疗试验的未来前景。这 建议书概述了开发临床试验的关键初始步骤 允许长期评估生活质量和 慢性神经系统疾病的经济后果。这将会实现的 延长普拉克索大型多中心临床试验的持续时间 与早期帕金森病患者的左旋多巴进行对比，并增加数据收集工作以 包括临床、生活质量、经济和功能成像结果。 这将解决患者和提供者关于最佳方法的问题 治疗早期帕金森病，以及提供多学科研究平台 (临床试验、生活质量评估和经济评估)进行培训 越来越多的内科教职员工和研究员 罗切斯特在理论、方法和实践方面的知识和 在以患者为中心的研究中从事富有成效的职业生涯的技能。霍洛威医生的 神经内科和社区科室的定位与预防 医学和罗切斯特临床研究课程将确保 招聘高素质实习生。

DESCRIPTION (provided by applicant): New insights into the pathogenesis of Parkinson's disease (PD), the availability of a wider array of anti-parkinsonian therapies, the evolution of better tools for evaluating and monitoring disease progression have combined to change the current management of PD and the future landscape of PDrelated therapeutic clinical trials. This proposal outlines the key initial steps to develop the clinical trial methodology that allows for the longterm assessment of quality of life and economic outcomes in chronic neurological conditions. This will be accomplished by extending the duration of large multicenter clinical trial of pramipexole versus levodopa in early PD and augmenting the data collection effort to include clinical, quality of life, economic, and functional imaging outcomes. This will address questions for patients and providers on the best approach to treating early PD, as well as to provide a multidisciplinary research platform (clinical trials, quality of life assessment, and economic evaluation) to train a growing number of physician faculty and fellows at the University of Rochester in the theoretical, methodological, and practical knowledge and skills for a productive career in patient-oriented research. Dr. Holloway's position within the Departments of Neurology and Community and Preventive Medicine, and the Rochester Clinical Research Curriculum will ensure the recruitment of highly qualified trainees.