Genetic Mechanisms of Cardiac Disease in the Young

D.伍德罗·本森医学博士，博士是一名儿科心脏病专家，长期致力于以患者为导向的研究。1995年，他在哈佛医学院塞德曼实验室进行了为期31个月的博士后研究，并接受了人类分子遗传学家的再培训。1998年1月，他被招募到南卡罗来纳州医科大学，建立一个心血管遗传学项目。他的长期研究目标是确定年轻人心血管疾病的分子基础;这项由NIH/NHLBI P50 HL 61006资助的提案旨在确定导致先天性心脏病的基因突变。本研究的目的是根据初步数据所证明的基本原理和可行性来制定的。该计划将为博士前学生和医学博士提供以患者为导向的研究指导。或博士希望从事临床研究的博士后学员。导师计划可以容纳合适的初级教员时，确定。该机构的环境是丰富的心血管研究和前和博士后水平的培训计划是实质性的。南卡罗来纳州儿童心脏中心有一个完善的以病人为导向的研究项目。有慷慨的机构支持，以建立一个程序的分子遗传学的先天性心脏病。所有的元素已经组装为建立一个丰富的环境，指导临床研究人员在年轻的心血管疾病的分子遗传学。在以患者为导向的研究中获得职业中期奖将使Benson博士能够将50%的精力投入到研究和指导临床研究者上。

D. Woodrow Benson, M.D., Ph.D. is a pediatric cardiologist with a career long commitment to patient-oriented research. In 1995 he retrained as a human molecular geneticist during a 31 month long post- doctoral fellowship in the Seidman Laboratory, Harvard Medical School. He was recruited to the Medical University of South Carolina in January, 1998 to establish a program in cardiovascular genetics. His long-term research objective is to determine the molecular basis of cardiovascular disease in the young; this proposal, funded by NIH/NHLBI P50 HL61006 seeks to identify genes whose mutations cause congenital heart defects. The aims of the research have been developed based upon the rationale and feasibility demonstrated in preliminary data. The proposed program will provide mentoring in patient-oriented research for predoctoral students and M.D. or Ph.D. postdoctoral trainees who wish to pursue careers in clinical research. The mentoring program cart accommodate .suitable junior faculty when identified. The institutional environment is rich in cardiovascular research and the pre- and postdoctoral level training programs are substantial. A well established patient-oriented research program exists in the South Carolina Children's Heart Center. There is generous institutional support to establish a program for molecular genetics of congenital heart disease. All elements have been assembled for building an enriched environment for mentoring clinical investigators in molecular genetics of cardiovascular disease in the young. Receipt of the Mid-Career Award in patient- oriented research will allow Dr. Benson to devote 50% effort to research and mentoring clinical investigators.