CLINICAL INVESTIGATOR TRAINING ENHANCEMENT: CITE PROGRAM

虽然在美国数以千计的临床科学家目前由个人或机构培训赠款资助，但由于这些学员通常分散在大学内的不同部门，部门和学校，因此通常不提供全面的教学研究课程。我们提出了一个为期2年的正式计划，致力于在临床研究的职业生涯博士后学员，题为临床研究者培训增强（CITE）计划。主要目标是：（1）制定和实施一个为期2年的正式临床研究课程，包括4个新课程的开发，以提供临床研究方法，生物统计学，流行病学，研究伦理，临床试验，转化研究，科学写作和拨款准备的培训;（2）创建一个指导有效性增强计划;（3）为CITE注册者开发一个新的临床研究硕士学位课程;（4）制作课程产品（网站、音频、视频），供当地使用和传播。印第安纳州大学（IU）在实现这些目标方面的优势包括在过去3年中完成的研究课程的重要初步工作，从50个培训赠款以及职业奖励中抽取的大量潜在参与者，72名参与教师和导师，拥有大量的校外资金组合，一个已资助超过35年的综合临床研究中心，一个大的不同的病人群体，并在这一建议的合作伙伴关系由IU的医学院，护理和牙科。参与者将参加8门必修课程，并可选择他们感兴趣的领域的其他选修课程，以获得临床研究硕士学位。除了一个主要的导师，每个学员将有一个正式的导师小组，约每4个月举行一次会议，并根据明确的基准监测进展情况，包括在2年计划结束时提交两份手稿和一份赠款提案。将编制教学大纲，以书面形式和专门网站传播。还将以录音带和录像带的形式提供课程的某些部分。印第安纳州大学CITE计划的成果将是职业临床研究人员的定期产出，一个8个组成部分的课程，可在各种媒体上使用，超出了我们自己的机构，以及指导临床研究的创新，将具有广泛的适用性。

While thousands of clinician-scientists in the U.S. are currently funded by individual or institutional training grants, a comprehensive didactic research curriculum is often not provided since such trainees are often scattered through separate divisions, departments and schools within the university. We propose a 2-year formal program for postdoctoral trainees committed to a career in clinical research, entitled the Clinical Investigator Training Enhancement (CITE) Program. The major aims are to: (1) Develop and implement a 2-year formal clinical research curriculum, including development of 4-new courses, to provide training in clinical research methods, biostatistics, epidemiology, research ethics, clinical trails, translational research, scientific writing, and grant preparation; (2) Create a mentoring effectiveness enhancement program; (3) Develop a new Masters of Clinical Research degree program for CITE enrollees; (4) Produce curricular products (website; audio; video) for both local use and dissemination. Strengths of Indiana University (IU) in achieving these aims include important preliminary work on research curricula done over the past 3 years, a large pool of potential participants drawn from 50 training grants as well as career awards, 72 participating faculty and mentors with a large portfolio of extramural funding, a General Clinical Research Center that has been funded for over 35 years, a large diverse patient population, and partnership in this proposal by IU's Schools of Medicine, Nursing and Dentistry. Participants will take 8 required courses with the option for other elective courses in their area of interest leading to a Masters of Clinical Research Degree. In addition to a primary mentor, each trainee will have a formal Mentor Panel that meets approximately every 4 months and monitors progress according to explicit benchmarks, including two manuscripts and one grant proposal by the end of the 2-year program. Syllabi will be developed for dissemination in both written form as well as a special website. Also selected components of the curriculum will be made available in audiotaped and videotaped formats. Outcomes of the Indiana University CITE Program will be regular output of career clinical researchers, an 8-component curriculum available in various media that is useful beyond our own institution, and innovations in mentoring clinical research that will have broad applicability.