Pesticides And Parkinson's Disease

目的：进行一项嵌套在农业健康研究队列中的帕金森病病例对照研究，以确定帕金森病风险的增加是否与以下因素有关：农药暴露、金属暴露、土壤微生物感染、微生物感染、土壤微生物生活方式因素包括饮食、吸烟、酒精和咖啡因使用异物代谢相关基因的多态性，或基因与环境的相互作用成就：该研究将是嵌套在农业健康研究中的病例对照研究，这是一项对82,000名获得许可的农药施用者及其配偶进行的大型队列研究。它将包括约160例病例和约480例对照。这项研究首次前瞻性地调查了农药暴露与帕金森病的关系，将直接暴露测量与详细的杀虫剂使用历史相结合。这项研究将极大地解决这一问题，因为几乎所有的队列成员都接触到了杀虫剂，尽管在接触特定化学品方面，队列中存在相当大的差异。我们已经制定了用于实地研究的方案和工具，预计将于2001年9月开始招募受试者。

Aims: To conduct a case-control study of PD nested in the Agricultural Health Study cohort, in order to determine whether increased risk of PD is associated with: pesticide exposure metal exposure exposure to Nocardia asteroides, a soil microorganism lifestyle factors including diet, cigarette smoking, and alcohol and caffeine use polymorphisms in genes involved in xenobiotic metabolism, or gene-environment interactions Accomplishments: The study will be a case-control study nested within the Agricultural Health Study, a large cohort study of 82,000 licensed pesticide applicators and their spouses. It will include ~160 cases and ~480 controls. This study is the first to investigate the relationship of pesticide exposure to PD prospectively, combining direct exposure measurements with detailed life histories of pesticide use. The study will have great power to address this issue, since virtually all cohort members are exposed to pesticides, although there is considerable variability within the cohort in exposure to specific chemicals. We have developed protocols and instruments for use in the field study, and expect to begin recruiting subjects in September, 2001.