CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION & GROWTH

描述：(改编自申请者摘要)调查员 建议确定妊娠和慢性疾病的机制 低氧影响子宫动脉的血管调节和生长，因此 会导致胎儿生长受限，并可能导致先兆子痫。这个 中枢工作假说是慢性低氧损害 子宫动脉的血管调节和生长相关反应。这个 假说将通过在三个具体的 目标。(1)确定怀孕和慢性低氧对 子宫动脉血管扩张剂/收缩药对生理性的反应 流量、压力和药理制剂的刺激；(2)确定 怀孕和/或慢性缺氧对子宫动脉生长的影响；以及 (3)确定怀孕和/或慢性缺氧对 子宫动脉血管调节受损指标与子宫动脉血流动力学指标的关系 生长到子宫动脉血流，宫内生长受限， 和先兆子痫。目标#1和#2将在孕妇和 未怀孕的豚鼠在整个妊娠期间保持在1600米和3962米的高度。 目标3侧重于居住在低海拔或高海拔地区的妇女 将使用多普勒血流测速仪和超声成像来测量 子宫动脉血流。

DESCRIPTION: (Adapted from applicant's abstract) The investigator proposes to determine the mechanisms by which pregnancy and chronic hypoxia influence uterine artery vasoregulation and growth, and thus contribute to fetal growth restriction and possibly pre-eclampsia. The central working hypothesis is that chronic hypoxia impairs vasoregulatory and growth related responses of the uterine artery. The hypothesis will be tested by experiments performed in three specific aims. (1) Determine the effects of pregnancy and chronic hypoxia on uterine artery vasodilators/constrictor responses to the physiological stimuli of flow, pressure, and pharmacological agents; (2) Determine the effect of pregnancy and/or chronic hypoxia on uterine artery growth; and (3) Determine the effect of pregnancy and/or chronic hypoxia on the relationship of indices of impaired uterine artery vasoregulation and growth to uterine artery blood flow, intrauterine growth restriction, and pre-eclampsia. Aims #1 and #2 are to be conducted on pregnant and non-pregnant guinea pigs kept at 1600m and 3962m throughout pregnancy. Aim #3 focuses on women residing at either low or high altitude in whom Doppler flow velocimetry and ultrasound imaging will be used to measure uterine artery blood flow.