Association of systemic inflammation with specific types of depressive symptoms: A new approach towards identifying the inflammatory subtypes of depr

全身性炎症与特定类型抑郁症状的关联：一种识别抑郁症炎症亚型的新方法摘要：全身性炎症与抑郁症的病理生理学有关。这一观点与抑郁症的细胞因子假说是一致的，该假说认为全身性炎症和随后的神经内分泌反应可以在一小部分个体中诱发抑郁样症状。然而，来自实验和观察研究的关于炎症-抑郁联系的集体证据并不一致。这种不一致可能归因于方法学的异质性，包括研究样本的差异（如临床与非临床）、样本量、结构测量和缺乏协变量调整。另一种可能性是，迄今为止，大多数研究都把抑郁症作为一种单一的广泛综合征来关注，从而忽视了炎症对抑郁症可能产生的症状或领域特异性影响。我的博士学位的总体目标是利用基因型和表型数据，探索全身性炎症与特定类型抑郁症状（即个体症状和症状域）之间的关联。

Complete title: Association of systemic inflammation with specific types of depressive symptoms: A new approach towards identifying the inflammatory subtypes of depressionSummary: Systemic inflammation has been implicated in the pathophysiology of depression. This notion is consistent with the cytokine hypothesis of depression, which posits that systemic inflammation and subsequent neuroendocrine responses can induce depressive-like symptoms in a subset of individuals. However, the collective evidence from both experimental and observational studies on the inflammation-depression link has been inconsistent. This discordance may be ascribed to methodological heterogeneity, including differences in the study samples (e.g., clinical versus non-clinical), sample sizes, measurement of constructs, and lack of covariate adjustment. Another possibility is that most studies to date have focused on depression as a single broad syndrome, thereby ignoring possible symptom- or domain-specific effects of inflammation on depression. The overall aim of my PhD is to explore the associations between systemic inflammation and specific types of depressive symptoms (i.e., individual symptoms and symptom domains), using both genotype and phenotype data.