Thermoregulatory Sequela of Traumatic Brain Injury

描述：（由申请人提供）本实验的目的是 表征创伤后高热（PTH）的动物模型，以便 未来的介入性研究可能会进行，然后转化为患者 在乎PTH是一种影响高达37%的患者的病症， 中重度创伤性脑损伤（TBI）。有充分的证据表明 损伤后高温会影响缺血动物模型的结果， 创伤性脑损伤体温过高会增加代谢消耗， 来维持肌肉或脂肪的储存。肌肉萎缩会显著 延长恢复最大功能所需的时间。此外，PTH是一种 排除诊断，要求患者接受多项 昂贵和痛苦的诊断测试。这种延误诊断也延误了 开始适当的治疗，因为发烧的传统干预措施 无效，并可能延迟转入康复治疗。迄今为止，研究表明， 只是为了确定发病率，因此很少有人知道， PTH现象。侧脑室注射甲状旁腺激素动物模型的建立 液压冲击损伤将提供关于该后遗症的所需知识， 特别是关于温度在损伤后即刻的影响 阶段诱导PTH的后续发展。甲状旁腺激素对 行为和认知也将在这项探索性研究中进行检查。 此外，这项研究的结果将提供有关 三种急性期反应物铜、锌和α-1之间的关系 抗胰蛋白酶，PTH，以确定其作为生物标志物的潜在用途。

DESCRIPTION: (provided by applicant) The goal of this experiment is to characterize an animal model of post-traumatic hyperthermia (PTH) in order that future interventional studies may be undertaken and then translated to patient care. PTH is a condition that affects up to 37% of patients with moderate-severe traumatic brain injuries (TBI). It has been well documented that hyperthermia post-injury worsens outcome in animal models of ischemia and TBI. Hyperthermia increases metabolic expenditure, resulting in the inability of patients to maintain muscle or fat stores. Muscle loss can significantly extend the time required to return to maximal function. Additionally, PTH is a diagnosis of exclusion, requiring the patient to be subjected to multiple costly and painful diagnostic tests. This delay in diagnosis also delays initiation of appropriate treatment as traditional interventions for fever are ineffective, and can delay transfer to rehabilitation. To date, studies have been aimed solely at determining incidence, thus very little is known about the phenomenon of PTH. The development of an animal model of PTH using lateral fluid percussion injury would provide needed knowledge about this sequela, particularly regarding the effect of temperature in the immediate post injury phase on inducing the subsequent development of PTH. The effect of PTH on behavior and cognition will also be examined in this exploratory study. Additionally, the findings of this study will provide information on the relationship of three acute phase reactants, copper, zinc, and alpha-1 antitrypsin, to PTH to determine their potential use as biological markers.