Human Motor Unit Discharge Variability

描述：(申请人提供)神经肌肉疾病，如中风或 多发性硬化症的后果会影响肌肉力量的控制。 尽管许多疾病的起源可能是中央确定的，但 力控制的基本单位，即马达单位，将反映 后果。有大量关于控制策略的信息，例如 关于招募机动部队的规定。我们不明白的是， 然而，运动单元中存在的可变性的性质和意义是什么？ 放电行为。持续时间内运动单位放电的波动 与这项研究相比，肌肉收缩很少受到关注 在心血管研究等环境中的可变性。仅仅是外表 对信号中随机噪声的估计往往会导致过早的结论。 然而，可能会出现病理性震颤等情况 从存在于电机单元放电波动内的结构。的确， 试点数据表明，非随机结构是这些波动所固有的 并进一步探讨了动车组的特点和意义 放电变化性。运动单位放电变异性将在以下几个方面进行比较 为精确控制或总力生产而设计的肌肉。这个 肌力和感官手法的影响将在 两种肌肉类型。这些实验条件中的每一个都将由 老年人和年轻人评估已知的与年龄相关的变化的影响 在运动单位形态上对运动单位放电的变异性。建议数 研究将系统地研究新的分析技术 马达单元研究。这些技术的信息内容将是 与已建立的分析方法提供的结果进行比较。喜欢这项研究 关于心率变异性，我希望提供有效的诊断工具 评估神经肌肉健康状况。

DESCRIPTION: (provided by applicant) Neuromuscular disorders such as stroke or multiple sclerosis have consequences that affect the control of muscular force. Even though the origin of many disorders may be centrally determined, the fundamental unit of force control, the motor unit, will reflect the consequences. There is abundant information on control strategies such as the rules governing the recruitment of motor units. What we do not understand, however, is the nature and meaning of variability that exists within motor unit discharge behavior. The fluctuations in motor unit discharge during sustained muscular contractions have received very little attention compared to the study of variability in settings such as cardiovascular research. The mere appearance of random noise in a signal has often resulted in premature conclusions. However, it may be the case that conditions such as pathological tremor result from structure that exists within motor unit discharge fluctuations. Indeed, pilot data indicate that non-random structure is inherent in these fluctuations and I wish to further explore the characteristics and meaning of motor unit discharge variability. Motor unit discharge variability will be compared among muscles that are designed for precision control or gross force production. The effects of muscular force and sensory manipulations will be investigated in both muscle types. Each of these experimental conditions will be performed by older and young individuals to evaluate the impact of known age-related changes in motor unit morphology on motor unit discharge variability. The proposed research will systematically investigate analytical techniques that are new to motor unit research. The information content of such techniques will be compared to that provided by established analytical methods. Like the research on heart rate variability, I hope to provide effective diagnostic tools for evaluating neuromuscular health.