Cylindrical Microfabrication of Stimulating Electrodes

说明（申请人提供）：目前存在几个问题 与外周功能性神经肌肉刺激假体相关。 这些问题包括由于闭合导致的导线断裂和电极移位 电极与收缩的肌肉的接近度。据推测， 脊髓功能性神经肌肉刺激系统将消除这些 问题为了创建这样的系统，需要微制造电极阵列， 开发该项目的目标是继续第一阶段的努力， 用于产生稳定和分级的肌肉的多个微制造电极 收缩力通过刺激位于哺乳动物的运动神经元 腰骶脊髓，最终用于恢复功能性运动， 瘫痪的人。 在该项目的第一阶段，工程设计中心（CED）开发了 微电极适合于刺激神经组织。初始 第二阶段项目的第二阶段将侧重于进一步开发和 表征微制造电极，其最终可以在 植入脊髓的阵列。阵列的多功能性 微电极将在体内进行测试，经皮连接器将 开发以允许长期研究。 拟议商业应用：不可用

DESCRIPTION (provided by applicant): There are several problems currently associated with peripheral functional neuromuscular stimulation prostheses. These problems include lead breakage and electrode migration due to the close proximity of the electrodes to the contracting muscles. It is postulated that a spinal cord functional neuromuscular stimulation system will eliminate these problems. To create such a system, microfabricated electrode arrays need to be developed. The goal of this project is to continue Phase I effort developing multiple microfabricated electrodes for producing stable and graded muscle contraction forces by stimulating motor neurons located in the mammalian lumbo-sacral spinal cord, ultimately for restoring functional motion to paralyzed individuals. In Phase I of this project, the Center for Engineering Design (CED) developed microelectrodes suitable for the stimulation of neural tissue. The initial phase of the Phase II project will focus on further developing and characterizing microfabricated electrodes that can eventually be fabricated in an array to be implanted in the spinal cord. The versatility of the arrayed microetectrodes will be tested in-vivo and percutaneous connectors will be developed to permit chronic studies. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE