Studies on Acceptability of Vaginal Microbicides

描述(改编自申请人的描述)：爆炸性质 南非疫情要求该国采取紧急措施预防艾滋病毒。 来自两个国家(约翰内斯堡和德班)的多学科研究小组 和两个国际网站(英国和美国)提出了一系列创新的研究 测定杀微生物剂的可接受性。申请者的丰富经验 在进行临床、行为、药物、社会、生物统计、流行病学 而卫生系统研究使他们处于独特的地位，可以进行广泛的 评估可接受性的研究。研究目标将分五个阶段阐述。 采用定性和定量相结合的方法。目标 包括：1.对与持续使用 参加第三阶段试验的性工作者的阴道杀菌剂； 2.开发衡量可接受性的标准化工具； 3.持续使用阴道相关因素的前瞻性评估 非临床环境中的杀微生物剂(如果有合适的产品)； 4.确定可接受的产品特性和交付机制 使用惰性产品的杀菌剂以及这些发现在评估中的应用 目前正在开发的几种产品的可接受性；以及5.识别 在健康人群中推广和使用杀微生物剂的促进者和障碍 南非的护理提供者和潜在使用者。

DESCRIPTION (Adapted from the applicant's description): The explosive nature of the South African epidemic calls for urgent measures for HIV prevention in the country. The multidisciplinary group of researchers from two National (Johannesburg and Durban) and two International sites (UK and USA) propose a series of innovative studies of determining acceptability of microbicides. The extensive experience of the applicants in conducting clinical, behavioral, pharmaceutical, social, biostatistics, epidemiological and health systems research places them in a unique position to conduct a wide range of studies to assess acceptability. The research objectives will be addressed in five phases with a combination of qualitative and quantitative methods. Objectives include: 1. Retrospective assessment of factors associated with continued use of a vaginal microbicide among sex workers who had participated in a Phase III trial; 2. Development of a standardized tool for measuring acceptability; 3. Prospective assessment of factors associated with continued use of a vaginal microbicide in a non-clinical setting (if appropriate products are available); 4. Ascertainment of acceptable product characteristics and delivery mechanisms for microbicides using inert products and application of these findings to assessing the acceptability of several products currently in development; and 5. Identification of facilitators and barriers to the introduction and use of microbicides among health care providers and potential users in South Africa.