ASCB Conf:Nontraditional Functions of Ubiquitin and UbLs

描述（由申请人提供）：“泛素和泛素样蛋白的非传统功能”会议将于2002年8月12日至8月14日在科罗拉多州科罗拉多斯普林斯的科罗拉多学院会议中心举行。本次会议由美国细胞生物学学会（ASCB）主办并部分资助。本次会议是今年唯一一次关注Ub非规范功能的国际会议，并向大量尚未成为泛素领域知名成员的年轻科学家开放。本次会议的目的是促进来自不同生物学背景的科学家之间的互动，他们正在研究泛素和ubl的非蛋白酶体依赖性作用。在此申请中，我们请求为2002年会议提供部分资金。越来越多的证据表明，泛素和ubl通过独立于蛋白酶体介导的降解的机制调节细胞功能。会议将集中讨论这些扩展的、新发现的功能，很少涉及蛋白酶体的蛋白质水解。泛素领域目前一些最令人兴奋的工作是在单泛素化领域，这是一种很少针对蛋白酶体底物的修饰。单泛素化和ubl的新作用将这些修饰物置于细胞生物学家感兴趣的核心过程中，包括生长因子受体的内吞作用、蛋白质运输、细胞内信号传导、炎症反应、病毒组装、发育、基因调控和DNA修复。特定蛋白质的单泛素化缺陷与严重高血压和几种癌症的遗传形式直接相关。泛素样蛋白也修饰蛋白，如p53肿瘤抑制因子及其专用的泛素连接酶Mdm2，在癌症预防中起着至关重要的作用。会议将召集来自这一广泛研究领域的科学家。上述议题将在2002年夏季会议的五个科学会议上讨论。这些会议将包括邀请的演讲和根据提交的摘要选择的演讲。后者的发言者将选择特别注意年轻的研究人员和令人兴奋的最新发展。还会有海报环节。会议的形式和规模较小，旨在促进200名与会者之间的互动。

DESCRIPTION (provided by applicant): The conference "Nontraditional Functions of Ubiquitin and Ubiquitin-Like Proteins (UbLs)" will be held from August 12 through August 14, 2002, at the Conference Center of Colorado College in Colorado Springs, Colorado. This meeting is sponsored and partially funded by the American Society for Cell Biology (ASCB). This conference is the only international meeting this year that focuses on noncanonical functions of Ub and is open to a significant number of young scientists who are not established members of the ubiquitin field. The purpose of this conference is to foster interactions between scientists from diverse biological backgrounds who are working on non-proteasome-dependent roles of ubiquitin and UbLs. In this application we request partial funding for the 2002 conference. Increasing evidence suggests that ubiquitin and UbLs regulate cell functions by mechanisms that are independent of proteasome-mediated degradation. The conference will focus on these expanding, newly-discovered functions, with little coverage of proteasomal proteolysis. Some of the most exciting current work in the ubiquitin field is in the area of monoubiquitination, a modification that seldom targets substrates to proteasomes. The emerging roles of monoubiquitination and UbLs squarely place these modifiers within processes of central interest to cell biologists, including the endocytosis of growth factor receptors, protein transport, intracellular signaling, the inflammatory response, viral assembly, development, gene regulation, and DNA repair. Defects in the monoubiquitination of specific proteins are directly linked to an inherited form of severe hypertension and several forms of cancer. Ubiquitin-like proteins also modify proteins, such as the p53tumor suppressor and its dedicated ubiquitin ligase, Mdm2, that play crucial roles in cancer prevention. The conference will convene scientists from this broad range of research areas. The aforementioned topics are among those to be addressed in the five scientific sessions of the 2002 ASCB Summer Conference. These sessions will consist of a mixture of invited talks and presentations to be selected based on submitted abstracts. The latter speakers will be chosen with special attention to younger investigators and exciting recent developments. There will also be a poster session. The format of the Conference, and its small size, are designed to foster interactions among the 200 participants.