Hormonal and Neural Peptide Biosynthesis (Gordon Confer)

描述(申请人提供)：第五届荷尔蒙和神经肽生物合成戈登研究会议将于2002年7月21-26日在新伦敦举行。这次会议已经成为一个重要的论坛，讨论处理酶和其他涉及内分泌和中枢神经系统内稳态和疾病的蛋白水解酶的快速发展领域。这次跨学科会议的主要焦点是内分泌和神经细胞中生物活性多肽合成的生物化学和细胞生物学，其范围包括了解多肽功能的分子生物学、生化、生物物理和遗传学方法。在产生生物活性多肽的细胞中发挥作用的多种相互作用负责许多生理调节过程和疾病的病因学，包括糖尿病、癌症、阿尔茨海默氏症和药物成瘾。为了解决这些问题，受邀的演讲者将从顶尖的资深科学家到初级科学家，提供最新的令人兴奋的数据，并为有希望的最新发展预留空间。会议将涉及激素和神经肽合成和加工的遗传学和生理学，蛋白质原加工酶的生物化学和结构分析，加工酶在人体生理和疾病中的作用，蛋白质分类和定位中的结构和调节，高尔基体的结构和功能，刺激响应室的形成，针对分泌颗粒和突触小泡的形成，胞吐作用的调节，以及多肽多样性的新方法。 由于其对内分泌和神经细胞生物化学的跨学科强调以及对人类生理学和疾病的整合，这次会议可能引起包括NIDDK、NINDS和NIDA在内的几个研究所的关注。在了解与内分泌和神经疾病相关的原蛋白加工、运输和分泌的几个方面的分子和细胞方面的进展将是这次会议的一个主要特点，并将彻底解决原蛋白加工、运输和分泌方面的障碍。正常生理和人类疾病都需要的蛋白酶系统的整合将与我们对糖尿病、癌症、阿尔茨海默氏症和药物成瘾的分子基础的理解有关。

DESCRIPTION (provided by applicant):The fifth Hormonal and Neural Peptide Biosynthesis Gordon Research Conference will be held from July 21-26, 2002 in New London, NH. This conference has established itself as an important forum for discussing the rapidly moving field of processing enzymes and other proteases involved in endocrine and CNS homeostasis and disease. The principal focus of this interdisciplinary meeting is on the biochemistry and cell biology of bioactive peptide synthesis in endocrine and neuronal cells, and its scope incorporates molecular biological, biochemical, biophysical, and genetic approaches to understanding peptide function. The multiple interactions that come into play in cells that produce bioactive peptides are responsible for many regulatory processes in physiology and the etiology of diseases, including diabetes, cancer, Alzheimer's, and drug addiction. To address these issues, invited speakers will range from leading senior scientists to junior scientists with recent, exciting data, with spaces reserved for promising late developments. The conference will cover the genetics and physiology of hormonal and neural peptide synthesis and processing, the biochemistry and structural analysis of proprotein processing enzymes, the role of processing enzymes in human physiology and disease, structure and regulation in protein sorting and localization, Golgi structure and function, formation of stimulus-responsive compartments, targeting to secretory granules and synaptic vesicles, regulation of exocytosis, and new approaches to peptide diversity. Because of its interdisciplinary emphasis on endocrine and neuronal cell biochemistry and its integration of human physiology and disease, this conference is of potential interest to the mission of several institutes, including NIDDK, NINDS and NIDA. Molecular and cellular advances in the understanding of several aspects of proprotein processing, trafficking, and secretion relevant to endocrine and neural diseases will be a central feature of the conference, and dysfunction in proprotein processing, trafficking and secretion will be thoroughly addressed. The integration of protease systems that are required both for normal physiology and human disease will be relevant to our understanding of the molecular bases of diabetes, cancer, Alzheimer's and drug addiction.