Gordon Conference on Environmental Endocrine Disruptors

第三届戈登环境内分泌干扰物研究会议将于2002年7月14日至19日在Mt.马萨诸塞州南哈德利的霍利奥克学院。这次会议比任何其他会议都更多地将不同的科学家群体聚集在一起，在这个跨学科的主题上进行互动。人类和野生动物暴露在大量已知或怀疑具有雌激素或抗雄激素活性或干扰甲状腺激素作用的广泛使用的环境化学品中。野生动物研究强烈表明，种群在许多方面受到这些环境内分泌干扰物(EEDs)的严重影响(内分泌和生殖系统失调、行为改变、畸形，从而减少繁殖和种群数量)。EED还被认为会导致人类生殖道畸形，以及睾丸和乳腺癌。美国、日本政府和欧盟正在收集信息，为大型研究工作提供资金，在某些情况下，还制定了监管EDS的法律。在美国，《安全饮用水法案》和《食品质量保护法》修正案要求对水和食品中发现的化学物质进行检测，以用于EED活动。环境内分泌干扰物戈登会议的目标将是：1)呈现所有复杂性水平(分子与种群)的最新研究，2)强调了解内分泌干扰的机械方法，3)努力整合从这些不同的研究领域和生物复杂性水平产生的数据，4)确定知识差距和新的探索研究领域，以及5)加强科学家之间的有效沟通，并促进新的合作研究努力。被邀请的演讲者名单上包括知名领导人以及最近报告了令人振奋的发现的年轻科学家。除了NIEHS，这次会议的跨学科性质可能引起其他几个机构的兴趣，包括NICHD(内分泌干扰物对男性和女性生殖道和乳腺的发育影响)、NIDDK(类固醇激素受体、甲状腺功能、生殖内分泌学)和NCI(致癌内分泌干扰物)。

The third Gordon Research Conference on Environmental Endocrine Disruptors will be held on July 14-19, 2002, at Mt. Holyoke College in South Hadley, Massachusetts. This conference, more than any other, will bring together a diverse group of scientists to interact in this interdisciplinary subject. Humans and wildlife are exposed to a large number of widely used environmental chemicals known or suspected to have either estrogenic or antiandrogenic activities, or to interfere with thyroid hormone action. Wildlife studies strongly suggest that populations are severely affected by these environmental endocrine disruptors (EEDs) in a number of ways (dysfunctional endocrine and reproductive systems, altered behavior, malformations, and thus reduced reproduction and population numbers). EEDs are also thought to cause malformations of the human genital tract as well as testicular and breast cancers. The US and Japanese governments and the European Union are gathering information, funding large research efforts, and in some cases, enacting laws regulating EEDs. In the US, amendments to the Safe Drinking Water Act and the Food Quality Protection Act mandate testing chemicals found in water and food for EED activity. The objectives of the Environmental Endocrine Disruptors Gordon Conference will be to: 1) present state-of-the-art research at all levels of complexity (molecular to population), 2) emphasize mechanistic approaches to the understanding of endocrine disruption, 3) work at integrating data emerging from these different fields of inquiry and levels of biological complexity, 4) identify gaps in knowledge and emerging areas of inquiry for exploration, and 5) enhance effective communication between scientists and foster new collaborative research efforts. The roster of invited speakers includes established leaders as well as young scientists who have recently reported exciting findings. In addition to the NIEHS, the interdisciplinary nature of this conference is of potential interest to several other institutes including the NICHD (developmental effects of endocrine disruptors on the male and female genital tract and mammary gland), the NIDDK (steroid hormone receptors, thyroid function, reproductive endocrinology) and the NCI (endocrine disruptors as carcinogens).