Development electro-mechanical model of the human heart for the study of heart failure.

心律失常是引起发病率和死亡率最高的心脏疾病。它们的特点是不规则的电激发波在心脏内传播，损害心脏组织的机械收缩，导致血液循环障碍。然而，在心力衰竭状态下心律失常和/或电-机械解耦的机制尚不完全清楚。在这个项目中，我们的目标是通过将心脏成像、电生理学和生物力学集成到一个完整的计算平台中来开发一种新型的心脏计算机模型。开发的模型将被用来研究心脏在心力衰竭情况下的机电特性。它的输出将增加我们对心力衰竭促心律失常作用的理解，这具有重要的临床意义。

Cardiac arrhythmia are the most comment cardiac disease causing morbidity and mortality. They are characterised by irregular electrical excitation waves propagating in the heart, which impair cardiac mechanical contraction of the tissue, leading to failure of blood circulation. However, it is incompletely understood yet the mechanism underling arrhythmogenesis and/or the electrical-mechanical uncoupling in the heart failure condition. In this project, we aim to develop a novel computer model of the heart by integrating cardiac imaging, electrophysiology and biomechanics into an integral computational platform. The developed model will be used to investigate the electromechanics of the heart in the setting of heart failure condition. The output of which will increase our understanding the pro-arrhythmic effects of heart failure, which has some important clinical relevance.