Clinical Investigations in Infectious and Autoimmune Diseases

免疫功能低下的患者表现出广泛的 各种特发性皮肤和粘膜病变，包括 皮炎、胃肠道和生殖道溃疡，以及 复发性口腔炎。这项研究的总体目标是 计划是评估粘膜炎症的发病机制 与HIV感染患者的免疫功能失调有关 口疮皮损。一项随机、对照的临床试验 作为多条调查路线的载体而启动的 旨在探讨口腔口疮的发病机制 溃疡，这是自发性的，复发性的粘膜溃疡。 未知的病因，并持续和衰弱的 艾滋病毒/艾滋病患者。目标是：1)评估临床 一种新型局部用药的药理学评价结果 沙利度胺制剂，2)评价局部给药的贡献 炎症过程在口腔溃疡发病机制中的作用 检测HIV感染者的细胞和分子水平 沙利度胺对炎性细胞和病变进展的影响 和愈合，3)检查慢性炎症的影响 口疮皮损及沙利度胺对HIV负荷的治疗 系统地和在口腔中，以及4)评估是否存在 病原体，包括艾滋病毒，作为潜在的致病因素 观察黏膜免疫反应。

Immunocompromised patients demonstrate a wide variety of idiopathic cutaneous and mucosal lesions including dermatitis, gastrointestinal and genital tract ulcerations, and recurrent aphthous stomatitis. The overall objective of this research program is to evaluate the pathogenesis of mucosal inflammation associated with immune dysregulation in HIV-infected patients with aphthous lesions. A randomized, controlled clinical trial was initiated which serves as a vehicle for several lines of inquiry directed towards investigating the pathogenesis of oral aphthous ulcers, which are spontaneous, recurrent mucosal ulcerations of unknown etiology, and which are persistent and debilitating in persons with HIV/AIDS. The objectives are to: 1) assess clinical outcomes in a pharmacologic evaluation of a novel topical thalidomide preparation, 2) evaluate the contribution of the local inflammatory process to the pathogenesis of aphthous ulcers in HIV-infected patients by examining the cellular and molecular effects of thalidomide on inflammatory cells and lesion progression and healing, 3) examine the effect of the chronic inflammation (aphthous lesions) and its treatment with thalidomide on HIV load systemically and in the oral cavity, and 4) evaluate presence of pathogens, including HIV, as potential causative agents for the observed mucosal immune response.